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Invitrogen
GLDC Polyclonal Antibody
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Product Details
PA5-51701
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human GLDC. Recombinant protein control fragment (Product #RP-101852).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2642028
Product Specific Information
Immunogen sequence: ILNANYMAKR LETHYRILFR GARGYVGHEF ILDTRPFKKS ANIEAVDVAK RLQDYGFHAP TMSWPVAGTL MVEPTESEDK AELDRFCDAM ISIRQEIADI EEGRIDPRVN PLKMSPHSLT CVTSSHWDRP YSREVAAFPL PFVKPENK
Highest antigen sequence identity to the following orthologs: Mouse - 96%, Rat - 96%.
Target Information
Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). The protein is the P protein, which binds to glycine and enables the methylamine group from glycine to be transferred to the T protein. Defects in this gene are a cause of nonketotic hyperglycinemia (NKH).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Glycine cleavage system P protein; glycine cleavage system protein P; Glycine decarboxylase; glycine decarboxylase P-protein; glycine decarboxylase, glycine cleavage system protein P); Glycine dehydrogenase (aminomethyl-transferring); glycine dehydrogenase (decarboxylating); Glycine dehydrogenase (decarboxylating), mitochondrial; glycine dehydrogenase (decarboxylating; glycine decarboxylase, glycine cleavage system protein P); glycine dehydrogenase [decarboxylating], mitochondrial; RP11-472F14.1
Gene Aliases: D030049L12Rik; D19Wsu57e; GCE; GCSP; GLDC; HYGN1
UniProt ID: (Human) P23378, (Mouse) Q91W43
Entrez Gene ID: (Human) 2731, (Mouse) 104174, (Rat) 309312
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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