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Immunogen sequence: MVDLCNSTK GICLTGPSGP PGPPGAGGLP GHNGLDGQPG PQGPKGEKGA NGKRGKMGIP GAAGNPGERG EKGDHGELGL QGNEGPPGQK GEKGDKGDVS NDVLLAGAKG D (1-110 aa encoded by BC113399)
CRG-L2 is a protein that contains olfactomedin-like and collagen-like domains. The encoded protein, which exists in both transmembrane and secreted forms, promotes formation of the nodes of Ranvier in the peripheral nervous system. Mutations in this gene cause a form of lethal congenital contracture syndrome in human patients. Autoantibodies to the encoded protein have been identified in sera form patients with multifocal motor neuropathy.
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Protein Aliases: cancer related gene - liver 2; Cancer-related gene liver 2 protein; collomin; colmedin; CRG-L2; FLJ23917; Gliomedin; olfactomedin-related protein
Gene Aliases: CLOM; COLM; CRG-L2; CRGL2; Crlg2; GLDN; UNC-112; UNQ9339/PRO34011
UniProt ID: (Human) Q6ZMI3, (Mouse) Q8BMF8
Entrez Gene ID: (Human) 342035, (Mouse) 235379
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