Proteintech

GLI1 Monoclonal Antibody (1D2B2)

FIGURE: 1 / 1

GLI1 Antibody (66905-1-IG) in WB

Various lysates were subjected to SDS PAGE followed by western blot with 66905-1-Ig (GLI1 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours.

Product Image Gallery

Product Details

66905-1-IG

Applications

Tested Dilution

Publications

Western Blot (WB)

1:3,000

View 50 publications 50 publications

Immunohistochemistry (IHC)

View 8 publications 8 publications

Immunocytochemistry (ICC/IF)

View 5 publications 5 publications

Immunoprecipitation (IP)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

1D2B2

Immunogen

GLI1 Fusion Protein Ag27832

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1000 µg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

Product Specific Information

Aliquoting is unnecessary for -20°C storage.

Target Information

This gene encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. Multiple transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Apatinib Suppresses Gastric Cancer Stem Cells Properties by Inhibiting the Sonic Hedgehog Pathway.

Frontiers in cell and developmental biology

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Apatinib Suppresses Gastric Cancer Stem Cells Properties by Inhibiting the Sonic Hedgehog Pathway.

Frontiers in cell and developmental biology

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Apatinib Suppresses Gastric Cancer Stem Cells Properties by Inhibiting the Sonic Hedgehog Pathway.

Frontiers in cell and developmental biology

Cao W,Li Y,Sun H,Yang C,Zhu J,Xie C,Li X,Wu J,Geng S,Wang L,Sun L,Geng G,Han H,Zhong C

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TSPAN8 promotes cancer cell stemness via activation of sonic Hedgehog signaling.

Nature communications

Zhu R,Gires O,Zhu L,Liu J,Li J,Yang H,Ju G,Huang J,Ge W,Chen Y,Lu Z,Wang H

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TSPAN8 promotes cancer cell stemness via activation of sonic Hedgehog signaling.

Nature communications

Zhu R,Gires O,Zhu L,Liu J,Li J,Yang H,Ju G,Huang J,Ge W,Chen Y,Lu Z,Wang H

Fri Jun 28 00:00:00 UTC 2019

Genistein inhibits nasopharyngeal cancer stem cells through sonic hedgehog signaling.

Phytotherapy research : PTR

Zhang Q,Cao WS,Wang XQ,Zhang M,Lu XM,Chen JQ,Chen Y,Ge MM,Zhong CY,Han HY

Tue Oct 01 00:00:00 UTC 2019

Sonic hedgehog pathway mediates genistein inhibition of renal cancer stem cells.

Oncology letters

Li E,Zhang T,Sun X,Li Y,Geng H,Yu D,Zhong C

Sun Sep 01 00:00:00 UTC 2019

Bioinformatics

Protein Aliases: GLI-Kruppel family member GLI1; Glioma-associated oncogene; glioma-associated oncogene 1; Glioma-associated oncogene homolog; glioma-associated oncogene homolog 1 (zinc finger protein); Oncogene GLI; zinc finger protein 5; Zinc finger protein GLI1

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Gene Aliases: AV235269; GLI; GLI1; Zfp-5; Zfp5

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UniProt ID: (Human) P08151, (Mouse) P47806

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Entrez Gene ID: (Human) 2735, (Rat) 140589, (Mouse) 14632

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Function(s)

RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding DNA binding chromatin binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding protein binding microtubule binding transcription regulatory region DNA binding metal ion binding molecular_function nucleic acid binding

Process(es)

osteoblast differentiation transcription from RNA polymerase II promoter smoothened signaling pathway spermatogenesis ventral midline development biological_process positive regulation of cell proliferation epidermal cell differentiation dorsal/ventral pattern formation proximal/distal pattern formation cerebellar cortex morphogenesis smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation pituitary gland development lung development positive regulation of DNA replication positive regulation of smoothened signaling pathway positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter notochord regression negative regulation of canonical Wnt signaling pathway transcription, DNA-templated regulation of smoothened signaling pathway response to wounding regulation of osteoblast differentiation digestive tract morphogenesis canonical Wnt signaling pathway liver regeneration regulation of hepatocyte proliferation regulation of transcription, DNA-templated signal transduction multicellular organism development cell differentiation

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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GLI1 Monoclonal Antibody (1D2B2)

GLI1 Antibody (66905-1-IG) in WB

Product Details

66905-1-IG

Western Blot (WB)

Immunohistochemistry (IHC)

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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