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Product Details
12678-1-AP
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
GLIS3 Fusion Protein Ag3366 (429-775 aa encoded by BC033899)
Conjugate
Form
Liquid
Concentration
0.29 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: LKIHLRSHT GEKPYLCQHP GCQKAFSNSS DRAKHQRTHL DTKPYACQIP GCTKRYTDPS SLRKHVKAHS SKEQQARKKL RSSTELHPDL LTDCLTVQSL QPATSPRDAA AEGTVGRSPG PGPDLYSAPI FSSNYSSRSG TAAGAVPPPH PVSHPSPGHN VQGSPHNPSS QLPPLTAVDA GAERFAPSAP SPHHISPRRV PAPSSILQRT QPPYTQQPSG SHLKSYQPET NSSFQPNGIH VHGFYGQLQK FCPPHYPDSQ RIVPPVSSCS VVPSFEDCLV PTSMGQASFD VFHRAFSTHS GITVYDLPSS SSSLFGESLR SGAEDATFLQ ISTVDRCPSQ LSSVYTEG (429-775 aa encoded by BC033899)
Target Information
This gene is a member of the GLI-similar zinc finger protein family and encodes a nuclear protein with five C2H2-type zinc finger domains. This protein functions as both a repressor and activator of transcription and is specifically involved in the development of pancreatic beta cells, the thyroid, eye, liver and kidney. Mutations in this gene have been associated with neonatal diabetes and congenital hypothyroidism (NDH). Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only two have been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GLI-similar 3; GLIS family zinc finger 3; OK/KNS-cl.4; Zinc finger protein 515; Zinc finger protein GLIS3
Gene Aliases: 4833409N03Rik; E330013K21Rik; GLIS3; NDH; RGD1565505; ZNF515
UniProt ID: (Human) Q8NEA6, (Mouse) Q6XP49
Entrez Gene ID: (Human) 169792, (Rat) 680671, (Mouse) 226075
DNA binding
metal ion binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
nucleic acid binding
transcription factor activity, sequence-specific DNA binding
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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