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GLP1R (extracellular) Antibody (AGR-021-F-50UL) in Flow
Cell surface detection of GLP1R inlive intact human MEG-01 megakaryoblastic leukemia cells: - (black line) cells. (red) Cells + rabbit IgG isotype control-FITC. (green) Cells + Anti-GLP1R (extracellular)-FITC Antibody (#AGR-021-F), (2.5 µg).
Product Details
AGR-021-F-50UL
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
(C)KYLYEDEG(S)WTRNS, corresponding to amino acid residues 288-301 of rat GLP1R, 2nd extracellular loop
Conjugate
Excitation/Emission Max
498/517 nm
View spectra
Form
Lyophilized
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles, store in dark
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitution: 50 µL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Target Information
Glucagon-like peptide-1(9-36)amide and GLP-1(9-37) are the forms of GLP-1 that result from the rapid degradation of the active forms of the peptide (GLP-1(7-36)amide and GLP-1(7-37)) by the enzyme dipeptidyl peptidase-IV (DPP-IV, also known as CD26 or adenosine deaminase binding protein). GLP-1 is a peptide hormone of the glucagon family, produced by the L cells of the intestinal mucosa from the same prohormone as glucagon. The active forms are potent stimulators of glucose-dependent insulin secretion. The sequence of GLP-1 is fully conserved in all mammalian species examined so far.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GLP-1 receptor; GLP-1-R; GLP-1R; GLP-I receptor; GLP1 receptor; Glucagon-like peptide 1 receptor; glucagon-like peptide-1 receptor; pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide 1; seven transmembrane helix receptor
Gene Aliases: Glip; GLP-1; GLP-1-R; GLP-1R; GLP1R; GLP1Rc; Glpr; RATGL1RCP
UniProt ID: (Human) P43220, (Mouse) O35659, (Rat) P32301
Entrez Gene ID: (Human) 2740, (Mouse) 14652, (Rat) 25051
response to stress
signal transduction
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
neuropeptide signaling pathway
learning or memory
memory
feeding behavior
regulation of heart contraction
positive regulation of cell proliferation
associative learning
response to glucose
cAMP-mediated signaling
insulin secretion
positive regulation of insulin secretion
negative regulation of apoptotic process
negative regulation of neuron apoptotic process
positive regulation of cell differentiation
positive regulation of blood pressure
positive regulation of heart contraction
positive regulation of transcription from RNA polymerase II promoter
hormone secretion
release of sequestered calcium ion into cytosol
regulation of calcium ion transport
activation of adenylate cyclase activity
regulation of insulin secretion
cellular response to glucagon stimulus
positive regulation of glucose import
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