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Invitrogen
GLRA1/GLRA2 Polyclonal Antibody
Product Details
PA1-84890
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to the N-terminal region of rat glycine receptor alpha 1 subunit.
Conjugate
Form
Lyophilized
Purification
Affinity chromatography
Storage buffer
Ammonium bicarbonate
Contains
no preservative
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2110058
Product Specific Information
PA1-84890 detects a band at ~48 kDa in rat spinal cord lysates.
Reconstitute with 0.1 mL PBS. For long term storage, the addition of 0.09% sodium azide is recommended. Prior to reconstitution, store at 4ºC. After reconstitution, store undiluted at -20ºC, avoiding freeze/thaw cycles.
Rabbit anti glycine receptor recognizes an epitope within the N-terminal region (NT) of glycine receptor alpha 1 and alpha 2 subunits.
Target Information
Glycine receptors are members of the ligand-gated ion channel superfamily, which mediate fast inhibitory neurotransmission. The receptors are pentameric membrane proteins which form chloride channels. Binding of glycine to its receptor produces an increase in chloride conductance and membrane hyperpolarisation. Four genes encoding glycine receptor alpha subunits have been identified, together with a single beta polypeptide. Each subunit consists of a large extracellular N-terminal region, four transmembrane domains, and a large cytoplasmic domain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Glycine receptor 48 kDa subunit; glycine receptor alpha 2 subunit; Glycine receptor alpha 2 subunit (glycine receptor, neonatal); Glycine receptor strychnine-binding subunit; Glycine receptor subunit alpha-1; Glycine receptor subunit alpha-2; glycine receptor, alpha 1 subunit; glycine receptor, alpha 2; glycine receptor, alpha 2 subunit; glycine receptor, alpha-2 polypeptide
Gene Aliases: GLR; GLRA1; GLRA2; Glyr; GLYRA1; HKPX1; nmf11; oscillator; ot; RNNEOGLY; spasmodic; spd; STHE
UniProt ID: (Human) P23415, (Human) P23416, (Mouse) Q64018, (Rat) P07727, (Rat) P22771, (Mouse) Q7TNC8
Entrez Gene ID: (Human) 2741, (Human) 2742, (Mouse) 14654, (Rat) 25674, (Rat) 24397, (Mouse) 237213
protein binding
zinc ion binding
glycine binding
extracellular-glycine-gated chloride channel activity
transmitter-gated ion channel activity
taurine binding
glycine-gated chloride ion channel activity
metal ion binding
extracellular ligand-gated ion channel activity
chloride channel activity
extracellular-glycine-gated ion channel activity
action potential
startle response
regulation of respiratory gaseous exchange by neurological system process
transport
ion transport
anion transport
chloride transport
muscle contraction
neuropeptide signaling pathway
chemical synaptic transmission
acrosome reaction
visual perception
adult walking behavior
ion transmembrane transport
regulation of membrane potential
regulation of respiratory gaseous exchange
neuromuscular process controlling posture
neuromuscular process
protein homooligomerization
protein heterooligomerization
negative regulation of transmission of nerve impulse
synaptic transmission, glycinergic
righting reflex
inhibitory postsynaptic potential
chloride transmembrane transport
positive regulation of acrosome reaction
synapse assembly
spinal cord development
cellular response to amino acid stimulus
cellular response to zinc ion
cellular response to ethanol
response to alcohol
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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