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Invitrogen
GLRX Polyclonal Antibody
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GLRX Antibody (PA5-102723) in IHC (P)
Immunohistochemistry analysis of paraffin-embedded GLRX in rat lung tissue. Antigen retrieval was performed using citrate buffer. Samples were blocked with blocking buffer (1.5 hr, 22°C), incubated with GLRX polyclonal antibody (Product # PA5-102723) using a dilution of 1:100 (1.5 hr, 22°C), followed by HRP conjugated goat anti-rabbit.
Product Details
PA5-102723
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human GLRX(Accession P35754), corresponding to amino acid residues M1-E44.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2852114
Product Specific Information
Antibody detects endogenous levels of total Glutaredoxin 1.
Target Information
Glutaredoxin (Grx), also known as thiol transferase, is a small heat-stable oxidoreductase. Grxs form part of the glutaredoxin system, comprising NADPH, GSH and glutathione reductase, which transfers electrons from NADPH to glutaredoxins via GSH. First recovered in E.coli as GSH-dependent hydrogen donors for ribonucleotide reductase, Grx catalyzes GSH-disulfide oxidoreductase via two redox-active cysteine residues. The active sequence (Cys-Pro-Tyr-Cys) is conserved in a variety of species. The 12-kDa dithiol protein has a role in reduction of mixed disulfides in cells exposed to oxidative stress.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: glutaredoxin (thioltransferase); glutaredoxin 1; glutaredoxin 1 (thioltransferase); Glutaredoxin-1; Glutaredoxin1; Grx 1; MGC117; MGC117407; thioltransferase; Thioltransferase 1; Thioltransferase-1; Thioltransferase1; TTase 1; TTase-1; TTase1
Gene Aliases: C86710; D13Wsu156e; GLRX; Glrx1; GRX; GRX1; TTase
UniProt ID: (Human) P35754, (Mouse) Q9QUH0, (Rat) Q9ESH6
Entrez Gene ID: (Human) 2745, (Mouse) 93692, (Rat) 64045
nucleobase-containing small molecule interconversion
cell redox homeostasis
positive regulation of membrane potential
oxidation-reduction process
protein deglutathionylation
positive regulation of sodium ion transmembrane transporter activity
transport
positive regulation of insulin secretion
positive regulation of exocytosis
positive regulation of cell adhesion molecule production
cellular response to estradiol stimulus
positive regulation of NIK/NF-kappaB signaling
negative regulation of hydrogen peroxide-mediated programmed cell death
negative regulation of platelet-derived growth factor receptor-beta signaling pathway
response to ischemia
aging
response to nutrient
ovulation cycle process
cellular response to glucose stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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