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Invitrogen
GLRX Polyclonal Antibody
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Product Details
PA5-70034
Product Specifications
Species Reactivity
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
synthetic peptide directed towards the middle region of human GLRX (aa 30-79)
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2690484
Product Specific Information
This target displays homology in the following species: Cow: 100%; Guinea Pig: 83%; Horse: 92%; Human: 100%; Mouse: 100%; Pig: 92%; Rabbit: 100%; Rat: 93%; Sheep: 100%
Target Information
Glutaredoxin (Grx), also known as thiol transferase, is a small heat-stable oxidoreductase. Grxs form part of the glutaredoxin system, comprising NADPH, GSH and glutathione reductase, which transfers electrons from NADPH to glutaredoxins via GSH. First recovered in E.coli as GSH-dependent hydrogen donors for ribonucleotide reductase, Grx catalyzes GSH-disulfide oxidoreductase via two redox-active cysteine residues. The active sequence (Cys-Pro-Tyr-Cys) is conserved in a variety of species. The 12-kDa dithiol protein has a role in reduction of mixed disulfides in cells exposed to oxidative stress.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: glutaredoxin 1; glutaredoxin 1 (thioltransferase); Glutaredoxin-1; Glutaredoxin1; Grx 1; MGC117; MGC117407; Thioltransferase 1; Thioltransferase-1; Thioltransferase1; TTase 1; TTase-1; TTase1
Gene Aliases: Glrx; Glrx1; Grx
UniProt ID: (Rat) Q9ESH6
Entrez Gene ID: (Rat) 64045
response to ischemia
aging
response to nutrient
ovulation cycle process
positive regulation of insulin secretion
cell redox homeostasis
positive regulation of membrane potential
positive regulation of exocytosis
oxidation-reduction process
positive regulation of cell adhesion molecule production
cellular response to glucose stimulus
cellular response to estradiol stimulus
positive regulation of NIK/NF-kappaB signaling
negative regulation of hydrogen peroxide-mediated programmed cell death
negative regulation of platelet-derived growth factor receptor-beta signaling pathway
positive regulation of sodium ion transmembrane transporter activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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