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Invitrogen
GLRX Recombinant Rabbit Monoclonal Antibody (3N3Y7)
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FIGURE: 1 / 1
GLRX Antibody (MA5-55455) in WB
Western Blot analysis of various lysates using GLRX Recombinant Monoclonal Antibody (Product # MA5-55455) at 1:1,000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) at 1:10,000 dilution. Lysates/proteins: 25 μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 60s.
Product Details
MA5-55455
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
3N3Y7
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 11-106 of human Glutaredoxin 1 (GLRX).
Conjugate
Form
Liquid
Concentration
1.14 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
RRID
AB_3667695
Product Specific Information
Immunogen Sequence: QPGKVVVFIK PTCPYCRRAQ EILSQLPIKQ GLLEFVDITA TNHTNEIQDY LQQLTGARTV PRVFIGKDCI GGCSDLVSLQ QSGELLTRLK QIGALQ
Target Information
Glutaredoxin (Grx), also known as thiol transferase, is a small heat-stable oxidoreductase. Grxs form part of the glutaredoxin system, comprising NADPH, GSH and glutathione reductase, which transfers electrons from NADPH to glutaredoxins via GSH. First recovered in E.coli as GSH-dependent hydrogen donors for ribonucleotide reductase, Grx catalyzes GSH-disulfide oxidoreductase via two redox-active cysteine residues. The active sequence (Cys-Pro-Tyr-Cys) is conserved in a variety of species. The 12-kDa dithiol protein has a role in reduction of mixed disulfides in cells exposed to oxidative stress.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: glutaredoxin (thioltransferase); glutaredoxin 1; glutaredoxin 1 (thioltransferase); Glutaredoxin-1; Glutaredoxin1; Grx 1; MGC117; MGC117407; thioltransferase; Thioltransferase 1; Thioltransferase-1; Thioltransferase1; TTase 1; TTase-1; TTase1
Gene Aliases: C86710; D13Wsu156e; GLRX; Glrx1; GRX; GRX1; TTase
UniProt ID: (Human) P35754, (Mouse) Q9QUH0, (Rat) Q9ESH6
Entrez Gene ID: (Human) 2745, (Mouse) 93692, (Rat) 64045
nucleobase-containing small molecule interconversion
cell redox homeostasis
positive regulation of membrane potential
oxidation-reduction process
protein deglutathionylation
positive regulation of sodium ion transmembrane transporter activity
transport
positive regulation of insulin secretion
positive regulation of exocytosis
positive regulation of cell adhesion molecule production
cellular response to estradiol stimulus
positive regulation of NIK/NF-kappaB signaling
negative regulation of hydrogen peroxide-mediated programmed cell death
negative regulation of platelet-derived growth factor receptor-beta signaling pathway
response to ischemia
aging
response to nutrient
ovulation cycle process
cellular response to glucose stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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