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GMF-beta Polyclonal Antibody

GMF-beta Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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GMF-beta Antibody (10690-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded mouse brain tissue slide using 10690-1-AP (GMF-beta antibody) at dilution of 1:200 (under 40x lens) heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

GMF-beta Antibody in Immunohistochemistry (PFA fixed) (IHC (PFA))

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Product Details

10690-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:3,000

View 6 publications 6 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunohistochemistry (PFA fixed) (IHC (PFA))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 4 publications 4 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Zebrafish

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

GMF-beta Fusion Protein Ag1104 (1-154 aa encoded by BC005359)

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.13 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MSESLVVCD VAEDLVEKLR KFRFRKETNN AAIIMKIDKD KRLVVLDEEL EGISPDELKD ELPERQPRFI VYSYKYQHDD GRVSYPLCFI FSSPVGCKPE QQMMYAGSKN KLVQTAELTK VFEIRNTEDL TEEWLREKLG FFTNVNFCVS KVFMY (1-154 aa encoded by BC005359)

Target Information

This protein, which is phosphorylated following phorbol ester stimulation, is important for the nervous system. It causes brain cell differentiation, stimulates neural regeneration and inhibits tumor cell proliferation. Overexpression of GMF in astrocytes has been shown to enhance brain-derived neurotrohic factor (BDNF) production. GMF expression is increased by exercise, and the protein is crucial for exercise-induction of BDNF. Through BDNF production, GMF appears to play a role in neuroprotection. In thymoma, T-cell development is maintained by GMF; being produced by the tumor cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Candidate biomarkers in brown adipose tissue for post-mortem diagnosis of fatal hypothermia.

International journal of legal medicine

Zhang M,Wang N,Guo XS,Wang LL,Wang PF,Cao ZP,Zhang FY,Wang ZW,Guan DW,Zhao R

Mon Jan 01 00:00:00 UTC 2024

Glia Maturation Factor β as a Novel Independent Prognostic Biomarker and Potential Therapeutic Target of Kidney Renal Clear Cell Carcinoma.

Frontiers in oncology

Zhu T,Wang T,Feng Z,Gao F,Zhang J,Jin C,Tian H,Xu J,Chen H,Ou Q,Wang J,Xu G,Lu L

Fri Jul 22 00:00:00 UTC 2022

Glia Maturation Factor β as a Novel Independent Prognostic Biomarker and Potential Therapeutic Target of Kidney Renal Clear Cell Carcinoma.

Frontiers in oncology

Zhu T,Wang T,Feng Z,Gao F,Zhang J,Jin C,Tian H,Xu J,Chen H,Ou Q,Wang J,Xu G,Lu L

Fri Jul 22 00:00:00 UTC 2022

Glia Maturation Factor Beta as a Novel Biomarker and Therapeutic Target for Hepatocellular Carcinoma.

Frontiers in oncology

Sun W,Hu C,Wang T,Wang J,Zhang J,Gao F,Ou Q,Tian H,Jin C,Xu J,Zhang J,Xu GT,Lu L

Sat Nov 20 00:00:00 UTC 2021

Glia maturation factor beta is required for reactive gliosis after traumatic brain injury in zebrafish.

Experimental neurology

Yin G,Du M,Li R,Li K,Huang X,Duan D,Ai X,Yao F,Zhang L,Hu Z,Wu B

Sun Jul 01 00:00:00 UTC 2018

Glia maturation factor beta is required for reactive gliosis after traumatic brain injury in zebrafish.

Experimental neurology

Yin G,Du M,Li R,Li K,Huang X,Duan D,Ai X,Yao F,Zhang L,Hu Z,Wu B

Sun Jul 01 00:00:00 UTC 2018

Glia maturation factor beta is required for reactive gliosis after traumatic brain injury in zebrafish.

Experimental neurology

Yin G,Du M,Li R,Li K,Huang X,Duan D,Ai X,Yao F,Zhang L,Hu Z,Wu B

Sun Jul 01 00:00:00 UTC 2018

Glia maturation factor beta is required for reactive gliosis after traumatic brain injury in zebrafish.

Experimental neurology

Yin G,Du M,Li R,Li K,Huang X,Duan D,Ai X,Yao F,Zhang L,Hu Z,Wu B

Sun Jul 01 00:00:00 UTC 2018

Co-Localization of Glia Maturation Factor with NLRP3 Inflammasome and Autophagosome Markers in Human Alzheimer's Disease Brain.

Journal of Alzheimer's disease : JAD

Ahmed ME,Iyer S,Thangavel R,Kempuraj D,Selvakumar GP,Raikwar SP,Zaheer S,Zaheer A

Wed May 30 00:00:00 UTC 2018

Co-Localization of Glia Maturation Factor with NLRP3 Inflammasome and Autophagosome Markers in Human Alzheimer's Disease Brain.

Journal of Alzheimer's disease : JAD

Ahmed ME,Iyer S,Thangavel R,Kempuraj D,Selvakumar GP,Raikwar SP,Zaheer S,Zaheer A

Wed May 30 00:00:00 UTC 2018

Dopaminergic Toxin 1-Methyl-4-Phenylpyridinium, Proteins α-Synuclein and Glia Maturation Factor Activate Mast Cells and Release Inflammatory Mediators.

PloS one

Kempuraj D,Thangavel R,Yang E,Pattani S,Zaheer S,Santillan DA,Santillan MK,Zaheer A

Tue May 10 00:00:00 UTC 2016

Dopaminergic Toxin 1-Methyl-4-Phenylpyridinium, Proteins α-Synuclein and Glia Maturation Factor Activate Mast Cells and Release Inflammatory Mediators.

PloS one

Kempuraj D,Thangavel R,Yang E,Pattani S,Zaheer S,Santillan DA,Santillan MK,Zaheer A

Tue May 10 00:00:00 UTC 2016

Dopaminergic Toxin 1-Methyl-4-Phenylpyridinium, Proteins α-Synuclein and Glia Maturation Factor Activate Mast Cells and Release Inflammatory Mediators.

PloS one

Kempuraj D,Thangavel R,Yang E,Pattani S,Zaheer S,Santillan DA,Santillan MK,Zaheer A

Tue May 10 00:00:00 UTC 2016

Dopaminergic Toxin 1-Methyl-4-Phenylpyridinium, Proteins α-Synuclein and Glia Maturation Factor Activate Mast Cells and Release Inflammatory Mediators.

PloS one

Kempuraj D,Thangavel R,Yang E,Pattani S,Zaheer S,Santillan DA,Santillan MK,Zaheer A

Tue May 10 00:00:00 UTC 2016

Coronary veins determine the pattern of sympathetic innervation in the developing heart.

Development (Cambridge, England)

Nam J,Onitsuka I,Hatch J,Uchida Y,Ray S,Huang S,Li W,Zang H,Ruiz-Lozano P,Mukouyama YS

Mon Apr 01 00:00:00 UTC 2013

Coronary veins determine the pattern of sympathetic innervation in the developing heart.

Development (Cambridge, England)

Nam J,Onitsuka I,Hatch J,Uchida Y,Ray S,Huang S,Li W,Zang H,Ruiz-Lozano P,Mukouyama YS

Mon Apr 01 00:00:00 UTC 2013

Identification of glia maturation factor beta as an independent prognostic predictor for serous ovarian cancer.

European journal of cancer (Oxford, England : 1990)

Li YL,Ye F,Cheng XD,Hu Y,Zhou CY,Lü WG,Xie X

Thu Jul 01 00:00:00 UTC 2010

Identification of glia maturation factor beta as an independent prognostic predictor for serous ovarian cancer.

European journal of cancer (Oxford, England : 1990)

Li YL,Ye F,Cheng XD,Hu Y,Zhou CY,Lü WG,Xie X

Thu Jul 01 00:00:00 UTC 2010

Identification of glia maturation factor beta as an independent prognostic predictor for serous ovarian cancer.

European journal of cancer (Oxford, England : 1990)

Li YL,Ye F,Cheng XD,Hu Y,Zhou CY,Lü WG,Xie X

Thu Jul 01 00:00:00 UTC 2010

Identification of glia maturation factor beta as an independent prognostic predictor for serous ovarian cancer.

European journal of cancer (Oxford, England : 1990)

Li YL,Ye F,Cheng XD,Hu Y,Zhou CY,Lü WG,Xie X

Thu Jul 01 00:00:00 UTC 2010

Bioinformatics

Protein Aliases: DNA for thyroid hormone receptor binding site (276bp); Glia maturation factor beta; glia maturation factor, beta; GMF-beta

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Gene Aliases: 3110001H22Rik; 3110001O16Rik; AI851627; C79176; D14Ertd630e; GMF; GMFB

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UniProt ID: (Human) P60983, (Rat) Q63228, (Mouse) Q9CQI3

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Entrez Gene ID: (Human) 2764, (Rat) 81661, (Mouse) 63985

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Function(s)

actin binding protein kinase inhibitor activity signal transducer activity enzyme activator activity growth factor activity Arp2/3 complex binding

Process(es)

learning locomotory behavior negative regulation of Arp2/3 complex-mediated actin nucleation protein phosphorylation negative regulation of protein kinase activity signal transduction nervous system development positive regulation of catalytic activity

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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GMF-beta Polyclonal Antibody

GMF-beta Antibody (10690-1-AP) in IHC (P)

Product Details

10690-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunohistochemistry (PFA fixed) (IHC (PFA))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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