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Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (PubMed:12009299, PubMed:12669231, PubMed:16359702, PubMed:22037469). Plays a role in modulating cellular differentiation (PubMed:12669231).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: GMP reductase 2; GMPR 2; Guanosine 5'-monophosphate oxidoreductase 2; Guanosine monophosphate reductase 2; guanosine monophosphate reductase isolog
Gene Aliases: 1810008P16Rik; 5730544D12Rik; AA959850; GMPR 2; GMPR2
UniProt ID: (Human) Q9P2T1, (Mouse) Q99L27
Entrez Gene ID: (Human) 51292, (Mouse) 105446, (Rat) 192357
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