Proteintech

GMPS Polyclonal Antibody

GMPS Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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GMPS Antibody (16376-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human liver cancer tissue slide using 16376-1-AP (GMPS antibody) at dilution of 1:100 (under 40x lens).

GMPS Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

16376-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:3,000

View 5 publications 5 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

GMPS Fusion Protein Ag9350 (345-693 aa encoded by BC012178)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.34 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: VKIANEVIG EMNLKPEEVF LAQGTLRPDL IESASLVASG KAELIKTHHN DTELIRKLRE EGKVIEPLKD FHKDEVRILG RELGLPEELV SRHPFPGPGL AIRVICAEEP YICKDFPETN NILKIVADFS ASVKKPHTLL QRVKACTTEE DQEKLMQITS LHSLNAFLLP IKTVGVQGDC RSYSYVCGIS SKDEPDWESL IFLARLIPRM CHNVNRVVYI FGPPVKEPPT DVTPTFLTTG VLSTLRQADF EAHNILRESG YAGKISQMPV ILTPLHFDRD PLQKQPSCQR SVVIRTFITS DFMTGIPATP GNEIPVEVVL KMVTEIKKIP GISRIMYDLT SKPPGTTEWE (345-693 aa encoded by BC012178)

Target Information

Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Mutant CHCHD10 causes an extensive metabolic rewiring that precedes OXPHOS dysfunction in a murine model of mitochondrial cardiomyopathy.

Cell reports

Sayles NM,Southwell N,McAvoy K,Kim K,Pesini A,Anderson CJ,Quinzii C,Cloonan S,Kawamata H,Manfredi G

Tue Mar 08 00:00:00 UTC 2022

The upregulated expression of RFC4 and GMPS mediated by DNA copy number alteration is associated with the early diagnosis and immune escape of ESCC based on a bioinformatic analysis.

Aging

Wang J,Luo FF,Huang TJ,Mei Y,Peng LX,Qian CN,Huang BJ

Tue Sep 14 00:00:00 UTC 2021

ERK2 Phosphorylates PFAS to Mediate Posttranslational Control of De Novo Purine Synthesis.

Molecular cell

Ali ES,Sahu U,Villa E,O'Hara BP,Gao P,Beaudet C,Wood AW,Asara JM,Ben-Sahra I

Thu Jun 18 00:00:00 UTC 2020

Nucleotide de novo synthesis increases breast cancer stemness and metastasis via cGMP-PKG-MAPK signaling pathway.

PLoS biology

Lv Y,Wang X,Li X,Xu G,Bai Y,Wu J,Piao Y,Shi Y,Xiang R,Wang L

Sun Nov 01 00:00:00 UTC 2020

Nucleotide de novo synthesis increases breast cancer stemness and metastasis via cGMP-PKG-MAPK signaling pathway.

PLoS biology

Lv Y,Wang X,Li X,Xu G,Bai Y,Wu J,Piao Y,Shi Y,Xiang R,Wang L

Sun Nov 01 00:00:00 UTC 2020

TRIM21-SERPINB5 aids GMPS repression to protect nasopharyngeal carcinoma cells from radiation-induced apoptosis.

Journal of biomedical science

Zhang P,Li X,He Q,Zhang L,Song K,Yang X,He Q,Wang Y,Hong X,Ma J,Liu N

Fri Jan 31 00:00:00 UTC 2020

TRIM21-SERPINB5 aids GMPS repression to protect nasopharyngeal carcinoma cells from radiation-induced apoptosis.

Journal of biomedical science

Zhang P,Li X,He Q,Zhang L,Song K,Yang X,He Q,Wang Y,Hong X,Ma J,Liu N

Fri Jan 31 00:00:00 UTC 2020

Bioinformatics

Protein Aliases: Glutamine amidotransferase; GMP synthase; GMP synthase [glutamine-hydrolyzing]; GMP synthetase; guanine monophosphate synthetase; guanine monphosphate synthetase; guanosine 5'-monophosphate synthase; MLL/GMPS fusion protein; testicular tissue protein Li 82

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Gene Aliases: AA591640; AI047208; GMPS

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UniProt ID: (Human) P49915, (Mouse) Q3THK7, (Rat) Q4V7C6

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Entrez Gene ID: (Human) 8833, (Mouse) 229363, (Rat) 295088

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Function(s)

GMP synthase activity GMP synthase (glutamine-hydrolyzing) activity ATP binding pyrophosphatase activity nucleotide binding ligase activity enzyme binding

Process(es)

GMP biosynthetic process glutamine metabolic process purine nucleobase biosynthetic process purine ribonucleoside monophosphate biosynthetic process purine nucleotide biosynthetic process response to drug

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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GMPS Polyclonal Antibody

GMPS Antibody (16376-1-AP) in IHC (P)

Product Details

16376-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunoprecipitation (IP)

Species Reactivity

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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