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Invitrogen
GNA13 Recombinant Rabbit Monoclonal Antibody (JE63-76)
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FIGURE: 1 / 3
GNA13 Antibody (MA5-44800) in IHC (P)
Immunohistochemistry analysis of GNA13 in paraffin-embedded mouse colon tissue. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0) for 2 minutes. The tissues were blocked in 1% BSA for 20 minutes at room temperature, washed with ddH2O and PBS, and then probed with GNA13 Monoclonal antibody (Product # MA5-44800) using a dilution of 1:400 for 1 hour at room t... View More
Product Details
MA5-44800
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
JE63-76
Immunogen
Recombinant protein within human GNA13 aa 278-377/377.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
TBS, pH 7.4, with 0.05% BSA, 40% glycerol
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2931257
Target Information
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:15240885, PubMed:16787920, PubMed:16705036, PubMed:27084452). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF1/p115RhoGEF, ARHGEF11/PDZ-RhoGEF and ARHGEF12/LARG) (PubMed:15240885, PubMed:12515866). GNA13-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway (PubMed:16787920, PubMed:16705036, PubMed:27084452). Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (PubMed:11976333). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: G alpha 13; G alpha-13; G-protein subunit alpha-13; Galpha 13; guanine nucleotide binding protein (G protein), alpha 13; guanine nucleotide binding protein, alpha 13; Guanine nucleotide-binding protein subunit alpha-13
Gene Aliases: AU024132; AU043124; G13; Galpha13; Gna-13; GNA13
UniProt ID: (Human) Q14344, (Mouse) P27601, (Rat) Q6Q7Y5
Entrez Gene ID: (Human) 10672, (Mouse) 14674, (Rat) 303634
angiogenesis
patterning of blood vessels
in utero embryonic development
signal transduction
G-protein coupled receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
small GTPase mediated signal transduction
Rho protein signal transduction
regulation of cell shape
cell differentiation
platelet activation
regulation of cell migration
activation of phospholipase D activity
intracellular signal transduction
movement of cell or subcellular component
metabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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