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Invitrogen
GNAI1/GNAI2/GNAI3 Recombinant Rabbit Monoclonal Antibody (HL2092)
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GNAI1/GNAI2/GNAI3 Antibody (MA5-50378) in IHC (P)
Immunohistochemical analysis of GNAI1/GNAI2/GNAI3 using GNAI1/GNAI2/GNAI3 Recombinant Monoclonal Antibody (Product # MA5-50378) in Paraffin embedded rat duodenum and kidney tissue at a dilution of 1:100. For Antigen retrieval citrate buffer, pH 6.0, as used for 15 min.
Product Details
MA5-50378
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat,
Zebrafish
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
HL2092
Immunogen
Recombinant fragment of human GNAI3.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_3094420
Target Information
GNAI1/GNAI2/GNAI3 are genes that encode for the G protein alpha inhibiting activity subunit. These proteins play a crucial role in signal transduction pathways, particularly in the inhibition of adenylyl cyclase. They are involved in various physiological processes, including neurotransmitter release, hormone secretion, and regulation of smooth muscle contraction. Mutations in these genes have been associated with various diseases, including hypoparathyroidism, pituitary adenoma, and cardiovascular disorders.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Adenylate cyclase-inhibiting G alpha protein; G alpha inhibitory type 2 (a); G alpha inhibitory type 2 (b); G(i) alpha-3; Galpha i1a; Galpha i3; Gi1 protein alpha subunit; GTP-binding protein (G-alpha-i2); GTP-binding regulatory protein Gi alpha-2 chain; guanine nucleotide binding protein (G protein), alpha inhibiting 1; guanine nucleotide binding protein (G protein), alpha inhibiting 2; guanine nucleotide binding protein (G protein), alpha inhibiting 3; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3; guanine nucleotide binding protein, alpha inhibiting 1; guanine nucleotide binding protein, alpha inhibiting 2; guanine nucleotide binding protein, alpha inhibiting 3; Guanine nucleotide binding, protein, alpha inhibiting polypeptide 3; Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding protein G(i) subunit alpha-2; Guanine nucleotide-binding protein G(i) subunit alpha-3; guanine nucleotide-binding protein G(i), alpha-1 subunit; guanine nucleotide-binding protein G(i), alpha-2 subunit; guanine nucleotide-binding protein G(k) subunit alpha; HG1B/HG1C/HG1A
Gene Aliases: 87U6; AI158965; ARCND1; AU046200; AW537698; BPGTPB; C76432; Galphai2; Galphai3; Gi; Gia; Gialpha1; GIP; GIP3A; Gnai-1; Gnai-2; Gnai-3; GNAI1; GNAI2; GNAI2B; GNAI3; H_LUCA15.1; H_LUCA16.1; zgc:63957
magnesium ion binding
G-protein coupled receptor binding
GTPase activity
signal transducer activity
protein binding
GTP binding
GDP binding
G-protein beta/gamma-subunit complex binding
G-protein coupled serotonin receptor binding
GTPase activating protein binding
metal ion binding
protein domain specific binding
nucleotide binding
guanyl nucleotide binding
signal transduction
G-protein coupled receptor signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
metabolic process
negative regulation of synaptic transmission
cell division
protein folding
transport
vesicle fusion
cell cycle
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
negative regulation of adenylate cyclase activity
dopamine receptor signaling pathway
GTP metabolic process
activation of MAPKK activity
adenosine receptor signaling pathway
G-protein coupled acetylcholine receptor signaling pathway
gamma-aminobutyric acid signaling pathway
G-protein coupled glutamate receptor signaling pathway
regulation of heart contraction
cell proliferation
positive regulation of cell proliferation
intracellular signal transduction
regulation of calcium ion transport
response to nutrient
response to peptide hormone
regulation of cAMP-mediated signaling
cellular response to forskolin
negative regulation of secretion
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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