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Product Details
68027-1-IG150UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Chicken,
Human,
Mouse,
Pig,
Rabbit,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1B5G2
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Target Information
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of second messenger signalling cascades. There are several types of Galpha proteins; Galphas and Galphai bind directly to adenylyl cyclase and stimulate or inhibit its activity, leading to an increase or decrease in cAMP levels respectively.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp686O0962; G alpha o; GNAO 1; Go alpha; GO2-q chimeric G-protein; GTP-binding protein alpha o; GTP-binding protein alpha-o subunit; guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O; guanine nucleotide binding protein, alpha O polypeptide 1; Guanine nucleotide-binding protein G(o) subunit alpha; guanine nucleotide-binding regulatory protein 2
Gene Aliases: alphaO; AW050213; EIEE17; G-ALPHA-o; Galphao; Gna0; GNAO; GNAO1; HLA-DQB1; RATBPGTPC
UniProt ID: (Human) P09471, (Rat) P59215, (Mouse) P18872
Entrez Gene ID: (Human) 2775, (Chicken) 415698, (Rat) 50664, (Mouse) 14681
GTPase activity
signal transducer activity
GTP binding
G-protein beta/gamma-subunit complex binding
G-protein coupled serotonin receptor binding
mu-type opioid receptor binding
GTPase activating protein binding
metal ion binding
corticotropin-releasing hormone receptor 1 binding
protein binding
GDP binding
protein complex binding
nucleotide binding
guanyl nucleotide binding
protein folding
muscle contraction
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
dopamine receptor signaling pathway
Wnt signaling pathway, calcium modulating pathway
aging
locomotory behavior
regulation of heart contraction
forebrain development
neuron projection development
response to cytokine
response to drug
response to hydrogen peroxide
response to morphine
positive regulation of GTPase activity
negative regulation of calcium ion transport
G-protein coupled receptor signaling pathway
metabolic process
cellular process
response to organonitrogen compound
response to organic cyclic compound
signal transduction
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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