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Proteintech
GNAS Monoclonal Antibody (1A9C10)
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Product Details
66253-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Pig
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
1A9C10
Immunogen
GNAS Fusion Protein Ag20530 (230-394 aa encoded by BC002722)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: ERRKWIQCF NDVTAIIFVV ASSSYNMVIR EDNQTNRLQE ALNLFKSIWN NRWLRTISVI LFLNKQDLLA EKVLAGKSKI EDYFPEFARY TTPEDATPEP GEDPRVTRAK YFIRDEFLRI STASGDGRHY CYPHFTCAVD TENIRRVFND CRDIIQRMHL RQYELL (230-394 aa encoded by BC002722)
Target Information
Mutations in GNAS gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseous heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors. This gene has a highly complex imprinted expression pattern. It encodes maternally, paternally, and biallelically expressed proteins which are derived from alternatively spliced transcripts with alternate 5' exons. Each of the upstream exons is within a differentially methylated region, commonly found in imprinted genes. However, the close proximity (14 kb) of two oppositely expressed promoter regions is unusual. In addition, one of the alternate 5' exons introduces a frameshift relative to the other transcripts, resulting in one isoform which is structurally unrelated to the others. An antisense transcript exists, and may regulate imprinting in this region. Mutations in this gene result in pseudohypoparathyroidism type 1a (PHP1a), which has an atypical autosomal dominant inheritance pattern requiring maternal transmission for full penetrance.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Adenylate cyclase-stimulating G alpha protein; alpha-stimulatory subunit of GTP-binding protein; Alternative gene product encoded by XL-exon; dJ309F20.1.1; dJ806M20.3.3; Extra large alphas protein; G protein subunit alpha S; guanine nucleotide binding protein (G protein), alpha stimulating activity polypeptide 1; guanine nucleotide regulatory protein; guanine nucleotide-binding protein G(s) subunit alpha; Guanine nucleotide-binding protein G(s) subunit alpha isoforms short; Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas; guanine nucleotide-binding protein, alpha-stimulating activity polypeptide 1; MGC33735; NESP55; neuroendocrine secretory protein; Neuroendocrine secretory protein 55; OTTHUMP00000031742; OTTHUMP00000196026; OTTHUMP00000196030; PHP1C; Protein ALEX; RP4-543J19.4; secretogranin VI; XLalphas; XLas
Gene Aliases: AHO; C20orf45; CH242-247L10.1; GNAS; GNAS1; GPSA; GSA; GSP; NESP; POH; PORGSA1; SCG6; SgVI
UniProt ID: (Human) O95467
Entrez Gene ID: (Human) 2778, (Pig) 100049657
GTPase activity
signal transducer activity
insulin-like growth factor receptor binding
protein binding
GTP binding
G-protein beta/gamma-subunit complex binding
beta-2 adrenergic receptor binding
D1 dopamine receptor binding
mu-type opioid receptor binding
ionotropic glutamate receptor binding
metal ion binding
corticotropin-releasing hormone receptor 1 binding
tissue homeostasis
endochondral ossification
energy reserve metabolic process
DNA methylation
adenylate cyclase-activating G-protein coupled receptor signaling pathway
adenylate cyclase-activating dopamine receptor signaling pathway
sensory perception of chemical stimulus
embryonic hindlimb morphogenesis
multicellular organism growth
post-embryonic body morphogenesis
response to drug
positive regulation of osteoblast differentiation
positive regulation of osteoclast differentiation
developmental growth
embryonic cranial skeleton morphogenesis
cognition
cartilage development
bone development
hair follicle placode formation
platelet aggregation
genetic imprinting
regulation of parathyroid hormone secretion
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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