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          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • GNAS Antibodies

          Proteintech

          GNAS Monoclonal Antibody (1A9C10), CoraLite® 594

          View all (40) GNAS antibodies

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          Cite GNAS Monoclonal Antibody (1A9C10), CoraLite® 594

          • Antibody Testing Data (5)
          GNAS Antibody in Immunocytochemistry (ICC/IF)
          Group 53 Created with Sketch.
          GNAS Antibody in Immunocytochemistry (ICC/IF)
          Group 53 Created with Sketch.

          FIGURE: 1 / 5

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          GNAS Antibody (CL59466253100UL) in ICC/IF

          Immunofluorescent analysis of (-20°C Methanol) fixed MCF-7 cells using CoraLite 594 GNAS antibody (Product # CL59466253100UL), Clone: 1A9C10 ) at dilution of 1:200. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          GNAS Antibody in Immunocytochemistry (ICC/IF)
          GNAS Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          GNAS Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          GNAS Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          GNAS Antibody in Flow Cytometry (Flow)

          Product Details

          CL59466253100UL

          Applications
          Tested Dilution
          Publications

          Immunohistochemistry (Paraffin) (IHC (P))

          1:200
          -

          Immunocytochemistry (ICC/IF)

          1:50-1:500
          -

          Flow Cytometry (Flow)

          0.4 µg
          -
          Product Specifications

          Species Reactivity

          Human

          Host/Isotype

          Mouse / IgG2b

          Class

          Monoclonal

          Type

          Antibody

          Clone

          1A9C10

          Conjugate

          CoraLite® 594 CoraLite® 594 CoraLite® 594
          • Unconjugated
          • CoraLite Plus 488
          • CoraLite Plus 647
          • Request custom conjugation

          Excitation/Emission Max

          593/614 nm

          Form

          Liquid

          Concentration

          1 mg/mL

          Purification

          Protein A

          Storage buffer

          PBS, pH 7.3, with 50% glycerol, 0.5% BSA

          Contains

          0.05% ProClin 300

          Storage conditions

          -20°C, Avoid Freeze/Thaw Cycles, store in dark

          Shipping conditions

          Wet ice

          Target Information

          Mutations in GNAS gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseous heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors. This gene has a highly complex imprinted expression pattern. It encodes maternally, paternally, and biallelically expressed proteins which are derived from alternatively spliced transcripts with alternate 5' exons. Each of the upstream exons is within a differentially methylated region, commonly found in imprinted genes. However, the close proximity (14 kb) of two oppositely expressed promoter regions is unusual. In addition, one of the alternate 5' exons introduces a frameshift relative to the other transcripts, resulting in one isoform which is structurally unrelated to the others. An antisense transcript exists, and may regulate imprinting in this region. Mutations in this gene result in pseudohypoparathyroidism type 1a (PHP1a), which has an atypical autosomal dominant inheritance pattern requiring maternal transmission for full penetrance.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          References (0)

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          Cite this product

          Bioinformatics

          Protein Aliases: Adenylate cyclase-stimulating G alpha protein; Alternative gene product encoded by XL-exon; dJ309F20.1.1; dJ806M20.3.3; Extra large alphas protein; G protein subunit alpha S; guanine nucleotide binding protein (G protein), alpha stimulating activity polypeptide 1; guanine nucleotide regulatory protein; Guanine nucleotide-binding protein G(s) subunit alpha isoforms short; Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas; MGC33735; NESP55; neuroendocrine secretory protein; Neuroendocrine secretory protein 55; OTTHUMP00000031742; OTTHUMP00000196026; OTTHUMP00000196030; PHP1C; Protein ALEX; RP4-543J19.4; secretogranin VI; XLalphas; XLas

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          Gene Aliases: AHO; C20orf45; GNAS; GNAS1; GPSA; GSA; GSP; NESP; POH; SCG6; SgVI

          View more View less

          UniProt ID: (Human) O95467

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          Entrez Gene ID: (Human) 2778

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          Function(s)
          GTPase activity signal transducer activity insulin-like growth factor receptor binding protein binding GTP binding G-protein beta/gamma-subunit complex binding beta-2 adrenergic receptor binding D1 dopamine receptor binding mu-type opioid receptor binding ionotropic glutamate receptor binding metal ion binding corticotropin-releasing hormone receptor 1 binding
          Process(es)
          tissue homeostasis endochondral ossification energy reserve metabolic process DNA methylation adenylate cyclase-activating G-protein coupled receptor signaling pathway adenylate cyclase-activating dopamine receptor signaling pathway sensory perception of chemical stimulus embryonic hindlimb morphogenesis multicellular organism growth post-embryonic body morphogenesis response to drug positive regulation of osteoblast differentiation positive regulation of osteoclast differentiation developmental growth embryonic cranial skeleton morphogenesis cognition cartilage development bone development hair follicle placode formation platelet aggregation genetic imprinting regulation of parathyroid hormone secretion
          It has to be done as per old AB suggested Products section.
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          If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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