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GNAT1 Polyclonal Antibody

GNAT1 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 4

GNAT1 Antibody (55167-1-AP) in ICC/IF

Immunofluorescent analysis of ( -20°C Ethanol ) fixed HeLa cells using 55167-1-AP (GNAT1 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

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Product Details

55167-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 5 publications 5 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunocytochemistry (ICC/IF)

1:50-1:500

View 1 publication 1 publication

Miscellaneous PubMed (MISC)

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse

Published species

Zebrafish

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.23 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody is specific to GNAT1.

Target Information

Transducin is a 3-subunit guanine nucleotide-binding protein (G protein) which stimulates the coupling of rhodopsin and cGMP-phosphodiesterase during visual impulses. The transducin alpha subunits in rods and cones are encoded by separate genes. This gene encodes the alpha subunit in rods. This gene is also expressed in other cells, and has been implicated in bitter taste transduction in rat taste cells. Mutations in this gene result in autosomal dominant congenital stationary night blindness. Multiple alternatively spliced variants, encoding the same protein, have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Deletion of Emc1 in photoreceptor cells causes retinal degeneration in mice.

The FEBS journal

Li X,Jiang Z,Su Y,Wang K,Jiang X,Sun K,Yang Y,Zhou Y,Zhu X,Zhang L

Fri Sep 01 00:00:00 UTC 2023

Deletion of Emc1 in photoreceptor cells causes retinal degeneration in mice.

The FEBS journal

Li X,Jiang Z,Su Y,Wang K,Jiang X,Sun K,Yang Y,Zhou Y,Zhu X,Zhang L

Fri Sep 01 00:00:00 UTC 2023

Knockout of DLIC1 leads to retinal cone degeneration via disturbing Rab8 transport in zebrafish.

Biochimica et biophysica acta. Molecular basis of disease

Zhang J,Jing M,Li P,Sun L,Pi X,Jiang N,Zhu KK,Li H,Li J,Wang M,Zhang J,Liu M,Mu H,Hu Y,Cui X

Sat Apr 01 00:00:00 UTC 2023

Frmpd1 Facilitates Trafficking of G-Protein Transducin and Modulates Synaptic Function in Rod Photoreceptors of Mammalian Retina.

eNeuro

Campla CK,Bocchero U,Strickland R,Nellissery J,Advani J,Ignatova I,Srivastava D,Aponte AM,Wang Y,Gumerson J,Martemyanov K,Artemyev NO,Pahlberg J,Swaroop A

Fri Oct 21 00:00:00 UTC 2022

Robust visual cortex evoked potentials (VEP) in Gnat1 and Gnat2 knockout mice.

Frontiers in cellular neuroscience

Flood MD,Veloz HLB,Hattar S,Carvalho-de-Souza JL

Wed Jan 11 00:00:00 UTC 2023

Identification of early-onset photoreceptor degeneration in transgenic mouse models of Alzheimer's disease.

iScience

Zhang J,Gao F,Ma Y,Xue T,Shen Y

Fri Nov 19 00:00:00 UTC 2021

Loss of PRCD alters number and packaging density of rhodopsin in rod photoreceptor disc membranes.

Scientific reports

Sechrest ER,Murphy J,Senapati S,Goldberg AFX,Park PS,Kolandaivelu S

Wed Oct 21 00:00:00 UTC 2020

Leveraging Zebrafish to Study Retinal Degenerations.

Frontiers in cell and developmental biology

Angueyra JM,Kindt KS

Wed Mar 13 00:00:00 UTC 2024

Leveraging Zebrafish to Study Retinal Degenerations.

Frontiers in cell and developmental biology

Angueyra JM,Kindt KS

Wed Mar 13 00:00:00 UTC 2024

Pathogenic mutations in retinitis pigmentosa 2 predominantly result in loss of RP2 protein stability in humans and zebrafish.

The Journal of biological chemistry

Liu F,Qin Y,Yu S,Soares DC,Yang L,Weng J,Li C,Gao M,Lu Z,Hu X,Liu X,Jiang T,Liu JY,Shu X,Tang Z,Liu M

Fri Apr 14 00:00:00 UTC 2017

Pathogenic mutations in retinitis pigmentosa 2 predominantly result in loss of RP2 protein stability in humans and zebrafish.

The Journal of biological chemistry

Liu F,Qin Y,Yu S,Soares DC,Yang L,Weng J,Li C,Gao M,Lu Z,Hu X,Liu X,Jiang T,Liu JY,Shu X,Tang Z,Liu M

Fri Apr 14 00:00:00 UTC 2017

Bioinformatics

Protein Aliases: guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1; Guanine nucleotide-binding protein G(t) subunit alpha-1; guanine nucleotide-binding protein G(T), alpha-1 subunit; rod-type transducin alpha subunit; Tr alpha; Transducin alpha-1 chain; transducin, rod-specific

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Gene Aliases: CSNB1G; CSNBAD3; GBT1; Gnat-1; GNAT1; GNATR; Ird1; Ird2; irdc; irdr; Tralpha; transducin

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UniProt ID: (Human) P11488, (Mouse) P20612

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Entrez Gene ID: (Human) 2779, (Mouse) 14685

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Function(s)

acyl binding G-protein coupled receptor binding GTPase activity signal transducer activity GTP binding GDP binding protein kinase binding G-protein beta/gamma-subunit complex binding metal ion binding nucleotide binding protein binding guanyl nucleotide binding

Process(es)

detection of chemical stimulus involved in sensory perception of bitter taste protein folding signal transduction adenylate cyclase-modulating G-protein coupled receptor signaling pathway visual perception phototransduction, visible light cell proliferation response to light stimulus response to light intensity rhodopsin mediated signaling pathway regulation of rhodopsin mediated signaling pathway eye photoreceptor cell development detection of light stimulus involved in visual perception sensory perception of umami taste positive regulation of cyclic-nucleotide phosphodiesterase activity negative regulation of cyclic-nucleotide phosphodiesterase activity retina development in camera-type eye cellular response to electrical stimulus G-protein coupled receptor signaling pathway G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger phototransduction response to stimulus

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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GNAT1 Polyclonal Antibody

GNAT1 Antibody (55167-1-AP) in ICC/IF

Product Details

55167-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunocytochemistry (ICC/IF)

Miscellaneous PubMed (MISC)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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