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Invitrogen
GNAT1 Polyclonal Antibody
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Product Details
PA1-724
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Human,
Sheep
Published species
Mouse,
Pig
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic Peptide: K(18) L K E D A E K D A R T V K(31) C
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 1mg/mL BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2247711
Product Specific Information
PA1-724 detects rod transducin alpha (Tr alpha) from bovine outer rod segments and sheep retinal extract.
PA1-724 has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~38 kDa protein representing Tr alpha from sheep retinal extract.
The PA1-724 immunizing peptide corresponds to amino acid residues 18-31 from human Tr alpha. This peptide (Cat. # PEP-153) is available for use in neutralization and control experiments.
Target Information
Transducin is a 3-subunit guanine nucleotide-binding protein (G protein) which stimulates the coupling of rhodopsin and cGMP-phosphodiesterase during visual impulses. The transducin alpha subunits in rods and cones are encoded by separate genes. This gene encodes the alpha subunit in rods. This gene is also expressed in other cells, and has been implicated in bitter taste transduction in rat taste cells. Mutations in this gene result in autosomal dominant congenital stationary night blindness. Multiple alternatively spliced variants, encoding the same protein, have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1; Guanine nucleotide-binding protein G(t) subunit alpha-1; guanine nucleotide-binding protein G(T), alpha-1 subunit; rod-type transducin alpha subunit; Tr alpha; Transducin alpha-1 chain; transducin, rod-specific
Gene Aliases: BOS_20922; CSNB1G; CSNBAD3; GBT1; GNAT1; GNATR
UniProt ID: (Human) P11488, (Bovine) P04695
Entrez Gene ID: (Human) 2779, (Sheep) 101121976, (Bovine) 281794
detection of chemical stimulus involved in sensory perception of bitter taste
protein folding
signal transduction
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
visual perception
phototransduction, visible light
cell proliferation
response to light stimulus
response to light intensity
rhodopsin mediated signaling pathway
regulation of rhodopsin mediated signaling pathway
eye photoreceptor cell development
detection of light stimulus involved in visual perception
sensory perception of umami taste
positive regulation of cyclic-nucleotide phosphodiesterase activity
negative regulation of cyclic-nucleotide phosphodiesterase activity
retina development in camera-type eye
cellular response to electrical stimulus
phototransduction
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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