Proteintech

GNMT Polyclonal Antibody

GNMT Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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GNMT Antibody (18790-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human prostate hyperplasia tissue slide using 18790-1-AP ( GNMT antibody) at dilution of 1:200 (under 40x lens).

GNMT Antibody in Immunoprecipitation (IP)

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Product Details

18790-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 22 publications 22 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Chicken, Mouse, Pig, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

GNMT Fusion Protein Ag4598 (1-295 aa encoded by BC032627)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.36 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MVDSVYRTR SLGVAAEGLP DQYADGEAAR VWQLYIGDTR SRTAEYKAWL LGLLRQHGCQ RVLDVACGTG VDSIMLVEEG FSVTSVDASD KMLKYALKER WNRRHEPAFD KWVIEEANWM TLDKDVPQSA EGGFDAVICL GNSFAHLPDC KGDQSEHRLA LKNIASMVRA GGLLVIDHRN YDHILSTGCA PPGKNIYYKS DLTKDVTTSV LIVNNKAHMV TLDYTVQVPG AGQDGSPGLS KFRLSYYPHC LASFTELLQA AFGGKCQHSV LGDFKPYKPG QTYIPCYFIH VLKRTD (1-295 aa encoded by B C032627)

Target Information

The protein encoded by this gene is an enzyme that catalyzes the conversion of S-adenosyl-L-methionine to S-adenosyl-L-homocysteine and sarcosine. The encoded protein is found in the cytoplasm and acts as a homotetramer. Defects in this gene are a cause of GNMT deficiency.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

In ovo injection of betaine promotes adrenal steroidogenesis in pre-hatched chicken fetuses.

Poultry science

Abobaker H,Omer NA,Hu Y,Idriss AA,Zhao R

Wed Jun 01 00:00:00 UTC 2022

Disrupted liver oxidative metabolism in glycine N-methyltransferase-deficient mice is mitigated by dietary methionine restriction.

Molecular metabolism

Rome FI,Hughey CC

Fri Apr 01 00:00:00 UTC 2022

Nuclear localization dictates hepatocarcinogenesis suppression by glycine N-methyltransferase.

Translational oncology

Simile MM,Cigliano A,Paliogiannis P,Daino L,Manetti R,Feo CF,Calvisi DF,Feo F,Pascale RM

Sat Jan 01 00:00:00 UTC 2022

Glycogen Storage Disease Phenotypes Accompanying the Perturbation of the Methionine Cycle in NDRG3-Deficient Mouse Livers.

Cells

Sohn HA,Lee DC,Park A,Kang M,Yoon BH,Lee CH,Kim YH,Oh KJ,Kim CY,Park SH,Koo H,Kim HC,Yoon WK,Lim DS,Kim D,Park KC,Yeom YI

Wed May 04 00:00:00 UTC 2022

MAT2A Localization and Its Independently Prognostic Relevance in Breast Cancer Patients.

International journal of molecular sciences

Chu PY,Wu HJ,Wang SM,Chen PM,Tang FY,Chiang EI

Thu May 20 00:00:00 UTC 2021

Maternal betaine supplementation decreases hepatic cholesterol deposition in chicken offspring with epigenetic modulation of SREBP2 and CYP7A1 genes.

Poultry science

Hu Y,Feng Y,Ding Z,Lv L,Sui Y,Sun Q,Abobaker H,Cai D,Zhao R

Mon Jun 01 00:00:00 UTC 2020

Transgenerational Inheritance of Betaine-Induced Epigenetic Alterations in Estrogen-Responsive IGF-2/IGFBP2 Genes in Rat Hippocampus.

Molecular nutrition & food research

Yang Y,Jiang W,Yang S,Qi F,Zhao R

Wed Apr 01 00:00:00 UTC 2020

Grandmaternal betaine supplementation enhances hepatic IGF2 expression in F2 rat offspring through modification of promoter DNA methylation.

Journal of the science of food and agriculture

Yang S,Zhao N,Sun B,Yang Y,Hu Y,Zhao R

Sun Mar 15 00:00:00 UTC 2020

Dietary betaine improves egg-laying rate in hens through hypomethylation and glucocorticoid receptor-mediated activation of hepatic lipogenesis-related genes.

Poultry science

Omer NA,Hu Y,Idriss AA,Abobaker H,Hou Z,Yang S,Ma W,Zhao R

Mon Jun 01 00:00:00 UTC 2020

Homocysteine impairs porcine oocyte quality via deregulation of one-carbon metabolism and hypermethylation of mitochondrial DNA†.

Biology of reproduction

Jia L,Zeng Y,Hu Y,Liu J,Yin C,Niu Y,Wang C,Li J,Jia Y,Hong J,Zhao R

Mon Apr 01 00:00:00 UTC 2019

Homocysteine impairs porcine oocyte quality via deregulation of one-carbon metabolism and hypermethylation of mitochondrial DNA†.

Biology of reproduction

Jia L,Zeng Y,Hu Y,Liu J,Yin C,Niu Y,Wang C,Li J,Jia Y,Hong J,Zhao R

Mon Apr 01 00:00:00 UTC 2019

DNA Hypomethylation of GR Promoters is Associated with GR Activation and BDNF/AKT/ERK1/2-Induced Hippocampal Neurogenesis in Mice Derived From Folic-Acid-Supplemented Dams.

Molecular nutrition & food research

Yang Y,Yang S,Liu J,Feng Y,Qi F,Zhao R

Sat Jun 01 00:00:00 UTC 2019

Elevated N-methyltransferase expression induced by hepatic stellate cells contributes to the metastasis of hepatocellular carcinoma via regulation of the CD44v3 isoform.

Molecular oncology

Li J,You S,Zhang S,Hu Q,Wang F,Chi X,Zhao W,Xie C,Zhang C,Yu Y,Liu J,Zhao Y,Liu P,Zhang Y,Wei X,Li Q,Wang X,Yin Z

Sun Sep 01 00:00:00 UTC 2019

Dietary betaine activates hepatic VTGII expression in laying hens associated with hypomethylation of GR gene promoter and enhanced GR expression.

Journal of animal science and biotechnology

Omer NA,Hu Y,Hu Y,Idriss AA,Abobaker H,Hou Z,Dong H,Zhao R

Fri Mar 11 00:00:00 UTC 2022

Maternal betaine supplementation attenuates glucocorticoid-induced hepatic lipid accumulation through epigenetic modification in adult offspring rats.

The Journal of nutritional biochemistry

Zhao N,Yang S,Jia Y,Sun B,He B,Zhao R

Sun Apr 01 00:00:00 UTC 2018

Maternal betaine supplementation attenuates glucocorticoid-induced hepatic lipid accumulation through epigenetic modification in adult offspring rats.

The Journal of nutritional biochemistry

Zhao N,Yang S,Jia Y,Sun B,He B,Zhao R

Sun Apr 01 00:00:00 UTC 2018

Mitotically Stable Modification of DNA Methylation in IGF2/H19 Imprinting Control Region Is Associated with Activated Hepatic IGF2 Expression in Offspring Rats from Betaine-Supplemented Dams.

Journal of agricultural and food chemistry

Yang S,Zhao N,Yang Y,Hu Y,Dong H,Zhao R

Wed Mar 21 00:00:00 UTC 2018

Mitotically Stable Modification of DNA Methylation in IGF2/H19 Imprinting Control Region Is Associated with Activated Hepatic IGF2 Expression in Offspring Rats from Betaine-Supplemented Dams.

Journal of agricultural and food chemistry

Yang S,Zhao N,Yang Y,Hu Y,Dong H,Zhao R

Wed Mar 21 00:00:00 UTC 2018

Corticosterone-Induced Lipogenesis Activation and Lipophagy Inhibition in Chicken Liver Are Alleviated by Maternal Betaine Supplementation.

The Journal of nutrition

Hu Y,Sun Q,Hu Y,Hou Z,Zong Y,Omer NA,Abobaker H,Zhao R

Thu Mar 01 00:00:00 UTC 2018

Corticosterone-Induced Lipogenesis Activation and Lipophagy Inhibition in Chicken Liver Are Alleviated by Maternal Betaine Supplementation.

The Journal of nutrition

Hu Y,Sun Q,Hu Y,Hou Z,Zong Y,Omer NA,Abobaker H,Zhao R

Thu Mar 01 00:00:00 UTC 2018

Maternal betaine supplementation in rats induces intergenerational changes in hepatic IGF-1 expression and DNA methylation.

Molecular nutrition & food research

Zhao N,Yang S,Hu Y,Dong H,Zhao R

Tue Aug 01 00:00:00 UTC 2017

Maternal betaine supplementation in rats induces intergenerational changes in hepatic IGF-1 expression and DNA methylation.

Molecular nutrition & food research

Zhao N,Yang S,Hu Y,Dong H,Zhao R

Tue Aug 01 00:00:00 UTC 2017

Downregulation of miR-150 Expression by DNA Hypermethylation Is Associated with High 2-Hydroxy-(4-methylthio)butanoic Acid-Induced Hepatic Cholesterol Accumulation in Nursery Piglets.

Journal of agricultural and food chemistry

Jia Y,Ling M,Zhang L,Jiang S,Sha Y,Zhao R

Wed Oct 12 00:00:00 UTC 2016

Downregulation of miR-150 Expression by DNA Hypermethylation Is Associated with High 2-Hydroxy-(4-methylthio)butanoic Acid-Induced Hepatic Cholesterol Accumulation in Nursery Piglets.

Journal of agricultural and food chemistry

Jia Y,Ling M,Zhang L,Jiang S,Sha Y,Zhao R

Wed Oct 12 00:00:00 UTC 2016

Folate deprivation induces cell cycle arrest at G0/G1 phase and apoptosis in hippocampal neuron cells through down-regulation of IGF-1 signaling pathway.

The international journal of biochemistry & cell biology

Yang Y,Li X,Sun Q,He B,Jia Y,Cai D,Zhao R

Sat Oct 01 00:00:00 UTC 2016

Folate deprivation induces cell cycle arrest at G0/G1 phase and apoptosis in hippocampal neuron cells through down-regulation of IGF-1 signaling pathway.

The international journal of biochemistry & cell biology

Yang Y,Li X,Sun Q,He B,Jia Y,Cai D,Zhao R

Sat Oct 01 00:00:00 UTC 2016

Abnormally activated one-carbon metabolic pathway is associated with mtDNA hypermethylation and mitochondrial malfunction in the oocytes of polycystic gilt ovaries.

Scientific reports

Jia L,Li J,He B,Jia Y,Niu Y,Wang C,Zhao R

Wed Jan 13 00:00:00 UTC 2016

Abnormally activated one-carbon metabolic pathway is associated with mtDNA hypermethylation and mitochondrial malfunction in the oocytes of polycystic gilt ovaries.

Scientific reports

Jia L,Li J,He B,Jia Y,Niu Y,Wang C,Zhao R

Wed Jan 13 00:00:00 UTC 2016

Maternal Betaine Supplementation throughout Gestation and Lactation Modifies Hepatic Cholesterol Metabolic Genes in Weaning Piglets via AMPK/LXR-Mediated Pathway and Histone Modification.

Nutrients

Cai D,Yuan M,Liu H,Pan S,Ma W,Hong J,Zhao R

Tue Oct 18 00:00:00 UTC 2016

Maternal Betaine Supplementation during Gestation Enhances Expression of mtDNA-Encoded Genes through D-Loop DNA Hypomethylation in the Skeletal Muscle of Newborn Piglets.

Journal of agricultural and food chemistry

Jia Y,Song H,Gao G,Cai D,Yang X,Zhao R

Wed Nov 25 00:00:00 UTC 2015

Maternal Betaine Supplementation during Gestation Enhances Expression of mtDNA-Encoded Genes through D-Loop DNA Hypomethylation in the Skeletal Muscle of Newborn Piglets.

Journal of agricultural and food chemistry

Jia Y,Song H,Gao G,Cai D,Yang X,Zhao R

Wed Nov 25 00:00:00 UTC 2015

Dietary betaine supplementation to gestational sows enhances hippocampal IGF2 expression in newborn piglets with modified DNA methylation of the differentially methylated regions.

European journal of nutrition

Li X,Sun Q,Li X,Cai D,Sui S,Jia Y,Song H,Zhao R

Thu Oct 01 00:00:00 UTC 2015

Dietary betaine supplementation to gestational sows enhances hippocampal IGF2 expression in newborn piglets with modified DNA methylation of the differentially methylated regions.

European journal of nutrition

Li X,Sun Q,Li X,Cai D,Sui S,Jia Y,Song H,Zhao R

Thu Oct 01 00:00:00 UTC 2015

Bioinformatics

Protein Aliases: 2.1.1.20; epididymis secretory sperm binding protein Li 182mP; Folate-binding protein; glycine methyltransferase; glycine N methyl transferase; Glycine N-methyltransferase

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Gene Aliases: Fbp-cII; GNMT; HEL-S-182mP

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UniProt ID: (Human) Q14749, (Mouse) Q9QXF8, (Rat) P13255

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Entrez Gene ID: (Human) 27232, (Mouse) 14711, (Rat) 25134

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Function(s)

protein binding folic acid binding glycine binding glycine N-methyltransferase activity methyltransferase activity transferase activity S-adenosylmethionine-dependent methyltransferase activity

Process(es)

glycogen metabolic process regulation of gluconeogenesis cellular protein modification process methionine metabolic process one-carbon metabolic process methylation glyoxylate metabolic process S-adenosylmethionine metabolic process protein homotetramerization glycine metabolic process S-adenosylhomocysteine metabolic process folic acid metabolic process protein tetramerization sarcosine metabolic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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GNMT Polyclonal Antibody

GNMT Antibody (18790-1-AP) in IHC (P)

Product Details

18790-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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