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Product Details
H00002801-D01P
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
GOLGA2 (NP_004477.2, 1 a.a. approximately 990 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Cell lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MSEETRQSKL AAAKKKLREY QQRNSPGVPT GAKKKKKIKN GSNPETTTSG GCHSPEDTPK DNAATLQPSD DTVLPGGVPS PGASLTSMAA SQNHDADNVP NLMDETKTFS STESLRQLSQ QLNGLVCESA TCVNGEGPAS SANLKDLESR YQQLAVALDS SYVTNKQLNI TIEKLKQQNQ EITDQLEEEK KECHQKQGAL REQLQVHIQT IGILVSEKAE LQTALAHTQH AARQKEGESE DLASRLQYSR RRVGELERAL SAVSTQQKKA DRYNKELTKE RDALRLELYK NTQSNEDLKQ EKSELEEKLR VLVTEKAGMQ LNLEELQKKL EMTELLLQQF SSRCEAPDAN QQLQQAMEER AQLEAHLGQV MESVRQLQME RDKYAENLKG ESAMWRQRMQ QMSEQVHTLR EEKECSMSRV QELETSLAEL RNQMAEPPPP EPPAGPSEVE QQLQAEAEHL RKELEGLAGQ LQAQVQDNEG LSRLNREQEE RLLELERAAE LWGEQAEARR QILETMQNDR TTISRALSQN RELKEQLAEL QSGFVKLTNE NMEITSALQS EQHVKRELGK KLGELQEKLS ELKETVELKS QEAQSLQQQR DQYLGHLQQY VAAYQQLTSE KEVLHNQLLL QTQLVDQLQQ QEAQGKAVAE MARQELQETQ ERLEAATQQN QQLRAQLSLM AHPGEGDGLD REEEEDEEEE EEEAVAVPQP MPSIPEDLES REAMVAFFNS AVASAEEEQA RLRGQLKEQR VRCRRLAHLL ASAQKEPEAA APAPGTGGDS VCGETHRALQ GAMEKLQSRF MELMQEKADL KERVEELEHR CIQLSGETDT IGEYIALYQS QRAVLKERHR EKEEYISRLA QDKEEMKVKL LELQELVLRL VGDRNEWHGR FLAAAQNPAD EPTSGAPAPQ ELGAANQQGD LCEVSLAGSV EPAQGEAREG SPRDNPTAQQ IMQLLREMQN PRERPGLGSN PCIPFFYRAD ENDEVKITVI
Target Information
Peripheral membrane component of the cis-Golgi stack that acts as a membrane skeleton that maintains the structure of the Golgi apparatus, and as a vesicle thether that facilitates vesicle fusion to the Golgi membrane. Required for normal protein transport from the endoplasmic reticulum to the Golgi apparatus and the cell membrane. Together with p115/USO1 and STX5, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus. Plays a central role in mitotic Golgi disassembly: phosphorylation at Ser-37 by CDK1 at the onset of mitosis inhibits the interaction with p115/USO1, preventing tethering of COPI vesicles and thereby inhibiting transport through the Golgi apparatus during mitosis. Also plays a key role in spindle pole assembly and centrosome organization.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 130 kDa cis-Golgi matrix protein; GM130; GM130 autoantigen; GOLGA; golgi autoantigen, golgin subfamily a, 2; Golgi matrix protein GM130; Golgin subfamily A member 2; Golgin-95; SY11 protein
Gene Aliases: GM130; GOLGA2
UniProt ID: (Human) Q08379
Entrez Gene ID: (Human) 2801
protein glycosylation
ER to Golgi vesicle-mediated transport
microtubule nucleation
asymmetric cell division
negative regulation of autophagy
negative regulation of protein binding
COPII vesicle coating
spindle assembly
protein homotetramerization
centrosome organization
positive regulation of protein glycosylation
Golgi ribbon formation
Golgi disassembly
spindle assembly involved in meiosis
mitotic spindle assembly
cell-cell adhesion
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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