Proteintech

GPD1L Polyclonal Antibody

FIGURE: 1 / 4

GPD1L Antibody (17263-1-AP) in WB

Human skeletal muscle tissue were subjected to SDS PAGE followed by western blot with 17263-1-AP (GPD1L antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

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Product Details

17263-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 6 publications 6 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

GPD1L Fusion Protein Ag10977 (1-351 aa encoded by BC028726)

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.13 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MAAAPLKVC IVGSGNWGSA VAKIIGNNVK KLQKFASTVK MWVFEETVNG RKLTDIINND HENVKYLPGH KLPENVVAMS NLSEAVQDAD LLVFVIPHQF IHRICDEITG RVPKKALGIT LIKGIDEGPE GLKLISDIIR EKMGIDISVL MGANIANEVA AEKFCETTIG SKVMENGLLF KELLQTPNFR ITVVDDADTV ELCGALKNIV AVGAGFCDGL RCGDNTKAAV IRLGLMEMIA FARIFCKGQV STATFLESCG VADLITTCYG GRNRRVAEAF ARTGKTIEEL EKEMLNGQKL QGPQTSAEVY RILKQKGLLD KFPLFTAVYQ ICYESRPVQE MLSCLQSHPE HT (1-351 aa encoded by BC028726)

Target Information

The protein encoded by this gene catalyzes the conversion of sn-glycerol 3-phosphate to glycerone phosphate. The encoded protein is found in the cytoplasm, associated with the plasma membrane, where it binds the sodium channel, voltage-gated, type V, alpha subunit (SCN5A). Defects in this gene are a cause of Brugada syndrome type 2 (BRS2) as well as sudden infant death syndrome (SIDS).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Uncoupled glycerol-3-phosphate shuttle in kidney cancer reveals that cytosolic GPD is essential to support lipid synthesis.

Molecular cell

Yao CH,Park JS,Kurmi K,Hu SH,Notarangelo G,Crowley J,Jacobson H,Hui S,Sharpe AH,Haigis MC

Thu Apr 20 00:00:00 UTC 2023

Atrial myocyte-derived exosomal microRNA contributes to atrial fibrosis in atrial fibrillation.

Journal of translational medicine

Hao H,Yan S,Zhao X,Han X,Fang N,Zhang Y,Dai C,Li W,Yu H,Gao Y,Wang D,Gao Q,Duan Y,Yuan Y,Li Y

Mon Sep 05 00:00:00 UTC 2022

Saturation of the mitochondrial NADH shuttles drives aerobic glycolysis in proliferating cells.

Molecular cell

Wang Y,Stancliffe E,Fowle-Grider R,Wang R,Wang C,Schwaiger-Haber M,Shriver LP,Patti GJ

Thu Sep 01 00:00:00 UTC 2022

A ferroptosis defense mechanism mediated by glycerol-3-phosphate dehydrogenase 2 in mitochondria.

Proceedings of the National Academy of Sciences of the United States of America

Wu S,Mao C,Kondiparthi L,Poyurovsky MV,Olszewski K,Gan B

Tue Jun 28 00:00:00 UTC 2022

Glycerol-3-phosphate biosynthesis regenerates cytosolic NAD⁺ to alleviate mitochondrial disease.

Cell metabolism

Liu S,Fu S,Wang G,Cao Y,Li L,Li X,Yang J,Li N,Shan Y,Cao Y,Ma Y,Dong M,Liu Q,Jiang H

Tue Oct 05 00:00:00 UTC 2021

A miR-210-3p regulon that controls the Warburg effect by modulating HIF-1α and p53 activity in triple-negative breast cancer.

Cell death & disease

Du Y,Wei N,Ma R,Jiang S,Song D

Wed Sep 09 00:00:00 UTC 2020

Bioinformatics

Protein Aliases: Glycerol-3-phosphate dehydrogenase 1-like protein; GPD1-L

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Gene Aliases: 2210409H23Rik; D9Ertd660e; GPD1-L; GPD1L; KIAA0089; RGD1560123

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UniProt ID: (Human) A8K9U3, (Mouse) Q3ULJ0

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Entrez Gene ID: (Human) 23171, (Mouse) 333433, (Rat) 363159

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Function(s)

glycerol-3-phosphate dehydrogenase [NAD+] activity sodium channel regulator activity protein homodimerization activity ion channel binding NAD binding oxidoreductase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor molecular_function

Process(es)

regulation of heart rate carbohydrate metabolic process glycerol-3-phosphate metabolic process NADH metabolic process positive regulation of sodium ion transport NAD metabolic process negative regulation of peptidyl-serine phosphorylation glycerol-3-phosphate catabolic process oxidation-reduction process regulation of ventricular cardiac muscle cell membrane depolarization ventricular cardiac muscle cell action potential negative regulation of protein kinase C signaling positive regulation of protein localization to cell surface regulation of sodium ion transmembrane transporter activity biological_process phosphatidic acid biosynthetic process triglyceride biosynthetic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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GPD1L Polyclonal Antibody

GPD1L Antibody (17263-1-AP) in WB

Product Details

17263-1-AP

Western Blot (WB)

Species Reactivity

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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