Alomone Labs, LTD

GPER (GPR30) Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

AER-050-200UL

Applications
Tested Dilution
Publications

Western Blot (WB)

1:200
-

Immunohistochemistry (IHC)

Assay-dependent
-
Product Specifications

Species Reactivity

Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

(C)ETFRDKLRLYVAQK, corresponding to amino acid residues 329-342 of rat GPER, Intracellular, C-terminus
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.85 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 1% BSA

Contains

0.05% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C, protected from the light, for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 X g 5 min).

Target Information

This gene is a member of the G-protein coupled receptor 1 family and encodes a multi-pass membrane protein that localizes to the endoplasmic reticulum. The protein binds estrogen, resulting in intracellular calcium mobilization and synthesis of phosphatidylinositol 3,4,5-trisphosphate in the nucleus. This protein therefore plays a role in the rapid nongenomic signaling events widely observed following stimulation of cells and tissues with estrogen. Alternate transcriptional splice variants which encode the same protein have been characterized.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Chemoattractant receptor-like 2; chemokine receptor-like 2; constitutively expressed peptide-like receptor like; G protein-coupled estrogen receptor 1; G protein-coupled receptor 30; G-protein coupled estrogen receptor 1; G-protein coupled receptor 30; G-protein coupled receptor 41; Membrane estrogen receptor; mER

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Gene Aliases: 6330420K13Rik; Ceprl; CMKRL2; FEG-1; GPCR-Br; Gper; Gper1; Gpr30; GPR41

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UniProt ID: (Rat) O08878, (Mouse) Q8BMP4

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Entrez Gene ID: (Rat) 171104, (Mouse) 76854

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Function(s)
chromatin binding steroid hormone receptor activity G-protein coupled receptor activity steroid binding drug binding mineralocorticoid receptor activity estrogen receptor activity hormone binding signal transducer activity
Process(es)
positive regulation of protein phosphorylation positive regulation of neurotransmitter secretion negative regulation of leukocyte activation inflammatory response positive regulation of cytosolic calcium ion concentration positive regulation of cell proliferation negative regulation of cell proliferation positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway positive regulation of gene expression negative regulation of gene expression positive regulation of phosphatidylinositol 3-kinase signaling neuronal action potential apoptotic chromosome condensation nuclear fragmentation involved in apoptotic nuclear change positive regulation of cell migration intracellular steroid hormone receptor signaling pathway positive regulation of cAMP biosynthetic process mineralocorticoid receptor signaling pathway positive regulation of insulin secretion positive regulation of inositol trisphosphate biosynthetic process positive regulation of apoptotic process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process steroid hormone mediated signaling pathway positive regulation of MAPK cascade innate immune response negative regulation of fat cell differentiation positive regulation of epidermal growth factor receptor signaling pathway positive regulation of G-protein coupled receptor protein signaling pathway positive regulation of vasodilation positive regulation of transcription from RNA polymerase II promoter negative regulation of inflammatory response positive regulation of neurogenesis negative regulation of DNA metabolic process negative regulation of lipid biosynthetic process positive regulation of release of sequestered calcium ion into cytosol regulation of cytosolic calcium ion concentration positive regulation of ERK1 and ERK2 cascade positive regulation of uterine smooth muscle contraction negative regulation of cell cycle arrest cellular response to glucose stimulus cellular response to tumor necrosis factor cellular response to peptide hormone stimulus cellular response to mineralocorticoid stimulus cellular response to estradiol stimulus positive regulation of establishment of protein localization to plasma membrane positive regulation of release of cytochrome c from mitochondria positive regulation of endothelial cell apoptotic process positive regulation of extrinsic apoptotic signaling pathway immune system process transcription from RNA polymerase II promoter apoptotic process cell cycle signal transduction G-protein coupled receptor signaling pathway nervous system development cell differentiation
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