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Invitrogen
GPR110 Polyclonal Antibody
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FIGURE: 1 / 2
GPR110 Antibody (PA5-100954) in ICC/IF
Immunocytochemistry analysis of GPR110 in HepG2 cells. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25°C. Samples were incubated with GPR110 polyclonal antibody (Product # PA5-100954) and mouse anti-beta tubulin antibody for 1 hour at 37°C. An AlexaFluor594 conjugated goat anti-rabbit IgG(H+L) (Red) and an AlexaFluor488 conjugated goat anti-mouse IgG(H+L) (Green) were used as the secondary antibodies. The nuclear counter stain is DAPI (blue).
Product Details
PA5-100954
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human ADGRF1(Accession Q5T601), corresponding to amino acid residues G838-H888.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2850441
Product Specific Information
Antibody detects endogenous levels of total GPR110.
Target Information
G protein-coupled receptors (GPRs), also known as seven transmembrane receptors, heptahelical receptors or 7TM receptors, comprise a superfamily of proteins that play a role in many different stimulus-response pathways. G protein coupled receptors translate extracellular signals into intracellular signals (G protein activation) and they respond to a variety of signaling molecules, such as hormones and neurotransmitters. GPR110 (G protein-coupled receptor 110), also known as PGR19, is a 911 amino acid protein that belongs to the G-protein coupled receptor 2 family and LN-TM7 subfamily. Characterized as an adhesion GPCR, GPR110 is a multipass membrane-bound protein with a long amino-terminus that contains multiple domains. One of these domains is the GPCR proteolytic site (GPS), which is essential for proteolytic cleavage of the amino-terminus and for cell surface expression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Adhesion G-protein coupled receptor F1; G protein-coupled receptor 110; G protein-coupled receptor KPG_012; G protein-coupled receptor PGR19; G-protein coupled receptor 110; G-protein coupled receptor KPG_012; internal gene name of KIRIN laboratory:M5; probable G-protein coupled receptor 110; seven transmembrane helix receptor
Gene Aliases: 5031409J19Rik; ADGRF1; GPR110; hGPCR36; KPG_009; KPG_012; PGR19
UniProt ID: (Human) Q5T601, (Mouse) Q8VEC3
Entrez Gene ID: (Human) 266977, (Mouse) 77596
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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