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Percent identity with other species by BLAST analysis: Human, Gorilla, Monkey, Marmoset, Mouse, Rat, Bat, Bovine, Hamster, Elephant, Panda, Horse, Rabbit, Pig, Turkey, Chicken, Lizard, Xenopus, Pufferfish, Zebrafish, Stickleback (100%).
For IHC(P), use heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.
The G-protein-coupled receptor (GPCR) superfamily is comprised of an estimated 600-1, 000 members and is the largest known class of molecular targets with proven therapeutic value. GPR22 is an orphan G-protein-coupled receptor, belonging to the class A rhodopsin-like GPCRs. GPR22 is highly expressed in several human brain regions, heart and coronary arteries. GPR22 expression is also observed in normal pancreas and in pancreatic, colorectal, prostate and liver cancer.
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Protein Aliases: G protein-coupled receptor 22; G protein-coupled receptor 22-like; G-protein coupled receptor 22; MGC129847; probable G-protein coupled receptor 22; putative G-protein coupled receptor; putative G-protein coupled receptor 22; tcag7.108
Gene Aliases: 2900068K05Rik; AW061316; BOS_4232; GPR22; I79_019574
UniProt ID: (Human) Q99680, (Rat) D4A3U0, (Mouse) Q8BZL4
Entrez Gene ID: (Bovine) 783685, (Human) 2845, (Chinese hamster) 100753963, (Rat) 298944, (Mouse) 73010, (Rabbit) 100345158
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