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Invitrogen
GPR26 Polyclonal Antibody
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Product Details
PA5-33683
Product Specifications
Species Reactivity
Dog,
Horse,
Human,
Non-human primate,
Pig
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic 18 amino acid peptide from 3rd cytoplasmic domain of human GPR26.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.1% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2551060
Target Information
The G-protein-coupled receptor (GPCR) superfamily is comprised of an estimated 600-1,000 members and is the largest known class of molecular targets with proven therapeutic value. GPR26 is a brain-specific orphan GPCR with a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. In the CNS, the highest GPR26 expression is in the amygdala, hippocampus and thalamus. Weak expression is detected in testis. GPR26 is down-regulated in glioblastoma. Depletion of GPR26 has been shown to increase fat storage in C. elegans, whereas GPR26 deficiency in the hypothalamus is associated with high genetic susceptibility to the onset of obesity in mice. GPR26 deficiency also causes metabolic complications commonly associated with obesity, including glucose intolerance, hyperinsulinemia, and dyslipidemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp761H2121; FLJ33774; G-protein coupled receptor 26; MGC138216
Gene Aliases: GPR26
UniProt ID: (Human) Q8NDV2
Entrez Gene ID: (Dog) 486926, (Human) 2849
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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