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Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Hamster (100%) Rabbit (93%) Bovine, Panda, Pig (80%).
The G-protein-coupled receptor (GPCR) superfamily is comprised of an estimated 600-1, 000 members and is the largest known class of molecular targets with proven therapeutic value. GPR3 is an orphan receptor with constitutive G signaling activity. GPR3 modulates a number of brain functions, including behavioral responses to stress, neurite outgrowth and amyloid-beta peptide generation suggesting that it may play a role in Alzheimer's disease.
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Protein Aliases: ACCA orphan receptor; adenylate cyclase constitutive activator; G protein-coupled receptor 3; G protein-coupled receptor R4; G-protein coupled receptor 3; G-protein-coupled receptor R4; GPCR21; Hacca; OTTHUMP00000043209
Gene Aliases: ACCA; Gpcr20; Gpcr21; Gpcr3; GPR3; I79_019963
UniProt ID: (Human) P46089, (Mouse) P35413, (Rat) Q8K1Q3
Entrez Gene ID: (Human) 2827, (Mouse) 14748, (Rat) 266769, (Chinese hamster) 100759546
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