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Invitrogen
GPR37 Polyclonal Antibody
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Product Details
PA5-33702
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic 20 amino acid peptide from N-terminal extracellular domain of human GPR37.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.1% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2551077
Product Specific Information
Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Rat, Elephant (95%) Hamster, Rabbit (90%) Mouse, Horse (85%).
Target Information
Parkinson is the second most common neurodegenerative disease after Alzheimers. About 1 percent of people over the age of 65 and 3 percent of people over the age of 75 are affected by the disease. The mutation is the most common cause of Parkinson disease identified to date. The function of Park2 is not well-known; however, it may play a role in the ubiquitin-mediated proteolytic pathway. Mutations in this gene are known to cause autosomal recessive juvenile parkinsonism. Alternative splicing of this gene produces three known products of undetermined function. Panneuronal expression of Parkin substrate Pael-R causes age-dependent selective degeneration of Drosophila dopaminergic (DA) neurons; coexpression of Parkin degrades Pael-R and suppresses its toxicity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Endothelin B receptor-like protein 1; ETBR-LP-1; G protein-coupled receptor 37 (endothelin receptor type B-like); G-protein coupled receptor 37; Gpcr/cns1; Het-b-r-lp; Pael receptor; PAELR; Parkin-associated endothelin receptor-like receptor; probable G-protein coupled receptor 37; Prosaposin receptor GPR37
Gene Aliases: EDNRBL; GPR37; hET(B)R-LP; PAELR
UniProt ID: (Human) O15354
Entrez Gene ID: (Human) 2861
G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
locomotion involved in locomotory behavior
dopamine biosynthetic process
positive regulation of MAPK cascade
positive regulation of dopamine metabolic process
negative regulation of hydrogen peroxide-induced cell death
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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