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Invitrogen
GPR68 Recombinant Rabbit Monoclonal Antibody (16H23L16)
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FIGURE: 1 / 5
GPR68 Antibody (702595) in IHC
Sections of human pancreas were dewaxed, microwaved in citric acid and incubated with Anti-GPR68 Recombinant Rabbit Monoclonal Antibody (Product # 702595, 1:500 dilution). Sections were then sequentially treated with biotinylated Anti-rabbit IgG and AB solution. Sections were then developed in AEC and lightly counterstained with hematoxylin.
Product Details
702595
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
Expi293
Class
Recombinant Monoclonal
Type
Antibody
Clone
16H23L16
Immunogen
Peptide corresponding to human GPR68 [aa342-aa365]
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2784550
Product Specific Information
This antibody is predicted to react with Monkey, Rat, Mouse, Horse.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Target Information
GPR68 (also known as OGR1 - ovarian cancer G-protein coupled receptor 1) is a proton-sensing receptor involved in pH homeostasis. It represents an osteoblastic pH sensor regulating the cell-mediated response to acidosis in bone. GPR68 mediates its action by association with G proteins that stimulate inositol phosphate (IP) production or CA2+ mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Also found to serve as a tumor suppressor in prostate cancer. Mutations to the gene result in amelogenesis imperfecta, hypomaturation type 2A6.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Brgr1; Brgrb; G-protein coupled receptor 68; GPR12A; OGR-1; ovarian cancer G protein-coupled receptor, 1; Ovarian cancer G-protein coupled receptor 1; Sphingosylphosphorylcholine receptor
Gene Aliases: GPR12A; GPR68; OGR1
UniProt ID: (Human) Q15743
Entrez Gene ID: (Human) 8111
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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