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Alomone Labs, LTD
GPR68 (OGR1) (extracellular) Polyclonal Antibody, FITC
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FIGURE: 1 / 2
GPR68 (OGR1) (extracellular) Antibody (AGR-042-F-50UL) in Flow
Cell surface detection of GPR68 in live intact human HL-60 acute promyelocytic leukemia cells: - (black line) cells. (red) Cells + Rabbit IgG Isotype Control-FITC. (green) Cells + Anti-GPR68 (OGR1) (extracellular) Antibody -FITC (#AGR-042-F), (2.5 µg).
Product Details
AGR-042-F-50UL
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
(C)HRV(S)FEHYPIQAWQR, corresponding to amino acid residues 169-183 of mouse GPR68, 2nd extracellular loop
Conjugate
Excitation/Emission Max
498/517 nm
View spectra
Form
Lyophilized
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles, store in dark
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitution: 15 µL or 50 µL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Target Information
GPR68 (also known as OGR1 - ovarian cancer G-protein coupled receptor 1) is a proton-sensing receptor involved in pH homeostasis. It represents an osteoblastic pH sensor regulating the cell-mediated response to acidosis in bone. GPR68 mediates its action by association with G proteins that stimulate inositol phosphate (IP) production or CA2+ mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Also found to serve as a tumor suppressor in prostate cancer. Mutations to the gene result in amelogenesis imperfecta, hypomaturation type 2A6.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Brgr1; Brgrb; G-protein coupled receptor 68; GPR12A; OGR-1; ovarian cancer G protein-coupled receptor, 1; Ovarian cancer G-protein coupled receptor 1; Sphingosylphosphorylcholine receptor
Gene Aliases: BB131428; GPR12A; GPR68; OGR1
UniProt ID: (Human) Q15743, (Mouse) Q8BFQ3
Entrez Gene ID: (Human) 8111, (Mouse) 238377, (Rat) 314386
signal transduction
G-protein coupled receptor signaling pathway
positive regulation of insulin secretion
positive regulation of insulin secretion involved in cellular response to glucose stimulus
negative regulation of monocyte differentiation
cellular response to pH
positive regulation of osteoclast development
inflammatory response
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