Invitrogen

GPX1 Recombinant Rabbit Monoclonal Antibody (JF0944)

View all (24) GPX1 antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MA5-41204

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

JF0944

Immunogen

recombinant protein

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

TBS, pH 7.4, with 40% glycerol, 0.05% BSA

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2898958

Target Information

Glutathione peroxidases (Gpxs) are ubiquitously expressed proteins which catalyze the reduction of hydrogen peroxides and organic hydroperoxides by glutathione. There are several isoforms which differ in their primary structure and localization. The classical cytosolic/mitochondrial GPx1 (cGPx) is a selenium-dependent enzyme, first of the GPx family to be discovered. GPx2, also known as gastrointestinal GPx (GI-GPx), is an intracellular enzyme expressed only at the epithelium of the gastrointestinal tract. Extracellular plasma GPx (pGPx or GPx3) is mainly expressed by the kidney from where it is released into the blood circulation. Phospholipid hydroperoxide GPx4 (PH-GPx) expressed in most tissues, can reduce many hydroperoxides including hydroperoxides integrated in membranes, hydroperoxy lipids in low density lipoprotein or thymine. All mammalian GPx family members, except for the recently described Cys containing GPx3 and epididymis-specific secretory GPx (eGPx or GPx5) isoforms, possess selenocysteine at the active site.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Cellular glutathione peroxidase; Glutathione peroxidase 1; GPx-1; HGNC:4553; MGC14399; MGC88245; OTTHUMP00000210766; Phospholipid-hydroperoxide glutathione peroxidase GPX1

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Gene Aliases: GPX1; GPXD; GSHPx; GSHPx-1; GSHPX1

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UniProt ID: (Human) P07203, (Rat) P04041

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Entrez Gene ID: (Human) 2876, (Rat) 24404

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Function(s)
glutathione peroxidase activity selenium binding SH3 domain binding glutathione binding phospholipid-hydroperoxide glutathione peroxidase activity
Process(es)
response to reactive oxygen species temperature homeostasis endothelial cell development negative regulation of inflammatory response to antigenic stimulus lipid metabolic process triglyceride metabolic process glutathione metabolic process apoptotic process response to oxidative stress response to lipid hydroperoxide aging sensory perception of sound cell proliferation intrinsic apoptotic signaling pathway in response to oxidative stress response to xenobiotic stimulus response to symbiotic bacterium response to wounding response to toxic substance UV protection response to hormone response to glucose response to selenium ion response to gamma radiation response to organic cyclic compound myotube differentiation protein oxidation response to estradiol response to hydroperoxide regulation of mammary gland epithelial cell proliferation response to nicotine regulation of gene expression, epigenetic vasodilation response to hydrogen peroxide hydrogen peroxide catabolic process negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process skeletal muscle tissue regeneration regulation of neuron apoptotic process blood vessel endothelial cell migration fat cell differentiation cell redox homeostasis skeletal muscle fiber development myoblast proliferation response to folic acid interaction with symbiont positive regulation of protein kinase B signaling heart contraction angiogenesis involved in wound healing regulation of proteasomal protein catabolic process negative regulation of release of cytochrome c from mitochondria negative regulation of extrinsic apoptotic signaling pathway via death domain receptors negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
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