Proteintech

GRAF Polyclonal Antibody

GRAF Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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GRAF Antibody (17747-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human heart using 17747-1-AP (GRAF antibody) at dilution of 1:50 (under 40x lens).

GRAF Antibody in Immunoprecipitation (IP)

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Product Details

17747-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 3 publications 3 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

GRAF Fusion Protein Ag12008 (403-759 aa encoded by BC068555)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.27 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: RGINEQGLY RIVGVNSRVQ KLLSVLMDPK TASETETDIC AEWEIKTITS ALKTYLRMLP GPLMMYQFQR SFIKAAKLEN QESRVSEIHS LVHRLPEKNR QMLQLLMNHL ANVANNHKQN LMTVANLGVV FGPTLLRPQE ETVAAIMDIK FQNIVIEILI ENHEKIFNTV PDMPLTNAQL HLSRKKSSDS KPPSCSERPL TLFHTVQSTE KQEQRNSIIN SSLESVSSNP NSILNSSSSL QPNMNSSDPD LAVVKPTRPN SLPPNPSPTS PLSPSWPMFS APSSPMPTSS TSSDSSPVST PFRKAKALYA CKAEHDSELS FTAGTVFDNV HPSQEPGWLE GTLNGKTGLI PENYVEFL (403-759 aa encoded by BC068555)

Target Information

Interaction of a cell with the extracellular matrix triggers integrin cell surface receptors to begin signaling cascades that regulate the organization of the actin-cytoskeleton. One of the proteins involved in these cascades is focal adhesion kinase. The protein encoded by this gene is a GTPase activating protein that binds to focal adhesion kinase and mediates the activity of the GTP binding proteins RhoA and Cdc42. Defects in this gene are a cause of juvenile myelomonocytic leukemia (JMML). Multiple transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

CEMIP, acting as a scaffold protein for bridging GRAF1 and MIB1, promotes colorectal cancer metastasis via activating CDC42/MAPK pathway.

Cell death & disease

Xu G,Zhao L,Hua Q,Wang L,Liu H,Lin Z,Jin M,Wang J,Zhou P,Yang K,Wu G,Yu D,Zhang D,Zhang T

Mon Feb 27 00:00:00 UTC 2023

CEMIP, acting as a scaffold protein for bridging GRAF1 and MIB1, promotes colorectal cancer metastasis via activating CDC42/MAPK pathway.

Cell death & disease

Xu G,Zhao L,Hua Q,Wang L,Liu H,Lin Z,Jin M,Wang J,Zhou P,Yang K,Wu G,Yu D,Zhang D,Zhang T

Mon Feb 27 00:00:00 UTC 2023

CEMIP, acting as a scaffold protein for bridging GRAF1 and MIB1, promotes colorectal cancer metastasis via activating CDC42/MAPK pathway.

Cell death & disease

Xu G,Zhao L,Hua Q,Wang L,Liu H,Lin Z,Jin M,Wang J,Zhou P,Yang K,Wu G,Yu D,Zhang D,Zhang T

Mon Feb 27 00:00:00 UTC 2023

Rho GTPase-activating protein 10 (ARHGAP10/GRAF2) is a novel autoantibody target in patients with autoimmune encephalitis.

Journal of neurology

Jarius S,Komorowski L,Regula JU,Haas J,Brakopp S,Wildemann B

Sat Oct 01 00:00:00 UTC 2022

Deficiency of NEAT1 prevented MPP⁺-induced inflammatory response, oxidative stress and apoptosis in dopaminergic SK-N-SH neuroblastoma cells via miR-1277-5p/ARHGAP26 axis.

Brain research

Zhou S,Zhang D,Guo J,Chen Z,Chen Y,Zhang J

Fri Jan 01 00:00:00 UTC 2021

Bioinformatics

Protein Aliases: FLJ42530; GRAF1; GTPase regulator associated with focal adhesion kinase; GTPase regulator associated with focal adhesion kinase pp125(FAK); Oligophrenin-1-like protein; Rho GTPase-activating protein 26; Rho-type GTPase-activating protein 26

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Gene Aliases: 1810044B20Rik; 2610010G17Rik; 4933432P15Rik; AI853435; ARHGAP26; GRAF; GRAF1; KIAA0621; mKIAA0621; OPHN1L; OPHN1L1

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UniProt ID: (Human) Q9UNA1, (Mouse) Q6ZQ82

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Entrez Gene ID: (Human) 23092, (Mouse) 71302

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Function(s)

GTPase activator activity protein binding phospholipid binding

Process(es)

signal transduction nervous system development actin cytoskeleton organization positive regulation of GTPase activity regulation of small GTPase mediated signal transduction plasma membrane organization

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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GRAF Polyclonal Antibody

GRAF Antibody (17747-1-AP) in IHC (P)

Product Details

17747-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunoprecipitation (IP)

Species Reactivity

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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