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Immunogen sequence: HLSRKKSSDS KPPSCSERPL TLFHTVQSTE KQEQRNSIIN SSLESVSSNP NSILNSSSSL QPNMNSSDPD LAVVKPTRPN SLPPNPSPTS
Interaction of a cell with the extracellular matrix triggers integrin cell surface receptors to begin signaling cascades that regulate the organization of the actin-cytoskeleton. One of the proteins involved in these cascades is focal adhesion kinase. The protein encoded by this gene is a GTPase activating protein that binds to focal adhesion kinase and mediates the activity of the GTP binding proteins RhoA and Cdc42. Defects in this gene are a cause of juvenile myelomonocytic leukemia (JMML). Multiple transcript variants encoding different isoforms have been found for this gene.
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Protein Aliases: FLJ42530; GRAF1; GTPase regulator associated with focal adhesion kinase; GTPase regulator associated with focal adhesion kinase pp125(FAK); Oligophrenin-1-like protein; Rho GTPase-activating protein 26; Rho-type GTPase-activating protein 26
Gene Aliases: ARHGAP26; GRAF; GRAF1; KIAA0621; OPHN1L; OPHN1L1
UniProt ID: (Human) Q9UNA1
Entrez Gene ID: (Human) 23092
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