Invitrogen

GREM1 Polyclonal Antibody

1 Published Figure
1 Reference
View all (16) GREM1 antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-47973

Applications
Tested Dilution
Publications

Immunohistochemistry (IHC)

-
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Immunohistochemistry (Paraffin) (IHC (P))

3-15 µg/mL
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Immunohistochemistry (Frozen) (IHC (F))

3-15 µg/mL
-

Neutralization (Neu)

1-3 µg/mL
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Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Goat / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Mouse myeloma cell line NS0-derived recombinant mouse Gremlin Lys25-Asp184
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS with 5% trehalose

Contains

No Preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2610125

Product Specific Information

In direct ELISAs, approximately 40% cross-reactivity with recombinant mouse (rm) PRDC/Gremlin-2 is observed, approximately 10% cross-reactivity with recombinant human (rh) Gremlin is observed and less than 5% cross-reactivity with rmDan, rhCerberus-1, and recombinant chicken Caronte is observed.

Reconstitute at 0.2 mg/mL in sterile PBS.

Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.

Target Information

In Xenopus, Gremlin belongs to a novel gene family that act as BMP antagonists in embryonic explants. The human homolog of Drm/Gremlin (CKTFS1B1) is localized on human chromosome 15q13--> q15. DRM-specific mRNA is expressed in different human tissues, including brain, ovary, intestine and colon. It has been suggested that down-regulation of DRM is associated with tumor progression, and support the hypothesis that human DRM may play an important role during both neuroembryological development and carcinogenesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: Cell proliferation-inducing gene 2 protein; colorectal adenoma and carcinoma 1; Cysteine knot superfamily 1, BMP antagonist 1; DAN domain family member 2; Down-regulated in Mos-transformed cells protein; down-regulated in v-mos-transformed cells; gremlin 1, cysteine knot superfamily, homolog; gremlin 1-like protein; Gremlin-1; IHG-2; Increased in high glucose protein 2; increased in high glucose-2

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Gene Aliases: C15DUPq; CKTSF1B1; CRAC1; CRCS4; DAND2; DRM; DUP15q; Grem; GREM1; GREMLIN; HMPS; HMPS1; IHG-2; ld; MPSH; PIG2

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UniProt ID: (Human) O60565, (Mouse) O70326

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Entrez Gene ID: (Human) 26585, (Mouse) 23892

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Function(s)
cytokine activity protein binding morphogen activity transmembrane receptor protein tyrosine kinase activator activity BMP binding vascular endothelial growth factor receptor 2 binding receptor agonist activity heparan sulfate proteoglycan binding
Process(es)
cell morphogenesis branching involved in ureteric bud morphogenesis cell migration involved in sprouting angiogenesis positive regulation of receptor internalization positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation mesenchymal to epithelial transition involved in metanephros morphogenesis apoptotic process signal transduction activation of transmembrane receptor protein tyrosine kinase activity cell-cell signaling positive regulation of cell proliferation proximal/distal pattern formation regulation of epithelial to mesenchymal transition collagen fibril organization negative regulation of cell growth embryonic limb morphogenesis negative regulation of bone mineralization negative regulation of BMP signaling pathway negative regulation of chondrocyte differentiation regulation of stress-activated MAPK cascade negative regulation of osteoblast proliferation positive regulation of NF-kappaB import into nucleus negative regulation of apoptotic process positive regulation of angiogenesis negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of bone remodeling determination of dorsal identity positive regulation of NF-kappaB transcription factor activity regulation of focal adhesion assembly positive regulation of telomerase activity limb development negative regulation of pathway-restricted SMAD protein phosphorylation ureteric bud formation positive regulation of protein tyrosine kinase activity signal transduction by p53 class mediator negative regulation of monocyte chemotaxis negative regulation of canonical Wnt signaling pathway positive regulation of branching involved in ureteric bud morphogenesis negative regulation of branching involved in ureteric bud morphogenesis negative regulation of osteoclast proliferation positive regulation of peptidyl-tyrosine autophosphorylation negative regulation of bone trabecula formation negative regulation of bone mineralization involved in bone maturation positive regulation of receptor activity positive regulation of cardiac muscle cell differentiation angiogenesis negative regulation of leukocyte chemotaxis organ morphogenesis endothelial cell migration positive regulation of transcription, DNA-templated
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