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Invitrogen
GRHL2 Polyclonal Antibody
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GRHL2 Antibody (PA5-87681) in WB
Western blot analysis of GRHL2 in extracts of various cell lines. Samples were incubated with GRHL2 Polyclonal antibody (Product # PA5-87681) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.
Product Details
PA5-87681
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 80-250 of human GRHL2 (NP_0791912)
Conjugate
Form
Liquid
Concentration
1.99 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2804342
Product Specific Information
Immunogen sequence: LSVSKASDSQ EDQEKRNCLG TSEAQSNLSG GENRVQVLKT VPVNLSLNQD HLENSKREQY SISFPESSAI IPVSGITVVK AEDFTPVFMA PPVHYPRGDG EEQRVVIFEQ TQYDVPSLAT HSAYLKDDQR STPDSTYSES FKDAATEKFR SASVGAEEYM YDQTSSGTFQ Y; Positive Samples: SH-SY5Y; Cellular Location: Membrane, Nucleus
Target Information
The protein encoded by this gene is a transcription factor that can act as a homodimer or as a heterodimer with either GRHL1 or GRHL3. Defects in this gene are a cause of non-syndromic sensorineural deafness autosomal dominant type 28 (DFNA28).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Brother of mammalian grainyhead; grainyhead-like 2; Grainyhead-like protein 2 homolog; grainyhead-like transcription factor 2; Transcription factor CP2-like 3
Gene Aliases: BOM; DFNA28; ECTDS; GRHL2; RGD1561191; TFCP2L3
UniProt ID: (Human) Q6NT03
Entrez Gene ID: (Human) 79977, (Rat) 299979
intronic transcription regulatory region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcription factor activity, sequence-specific DNA binding
protein binding
chromatin DNA binding
sequence-specific DNA binding
molecular_function
in utero embryonic development
neural tube closure
cardiac ventricle morphogenesis
epithelial cell morphogenesis
regulation of transcription from RNA polymerase II promoter
cell adhesion
brain development
biological_process
cell proliferation
epidermis development
regulation of gene expression
neural tube development
respiratory tube development
cell junction assembly
multicellular organism growth
embryonic digit morphogenesis
camera-type eye development
regulation of DNA methylation
negative regulation of keratinocyte differentiation
embryonic organ development
embryonic cranial skeleton morphogenesis
positive regulation of telomerase activity
face development
lung lobe morphogenesis
lung epithelial cell differentiation
bicellular tight junction assembly
epithelium migration
transcription from RNA polymerase II promoter
positive regulation of transcription from RNA polymerase II promoter
epithelial cell morphogenesis involved in placental branching
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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