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Alomone Labs, LTD
GRIK1 (GluK1) (extracellular) Polyclonal Antibody
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FIGURE: 1 / 3
GRIK1 (GluK1) (extracellular) Antibody (AGC-008-200UL) in ICC/IF
Expression of kainate receptor GluK1 in rat DRG neurons - Cell surface detection of kainate receptor GluK1 in living rat dorsal root ganglion (DRG). A. Extracellular staining of cells using Anti-GRIK1 (GluK1) (extracellular) Antibody (#AGC-008), (1:50) followed by goat Anti-rabbit-AlexaFluor-555 secondary Antibody (red). B. Live view of the same field.
Product Details
AGC-008-200UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
(C)KASGEVSKHLYKVWKK, corresponding to amino acid residues402-417 of ratkainate receptor GluK1, Extracellular, N-terminus
Conjugate
Form
Lyophilized
Concentration
0.8 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Target Information
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. Grik1, also known as glutamate receptor 5, belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. Grik1 is expressed in GABAergic interneurons of the hippocampus and are thought to participate in the formation of various subtypes of kainate receptors with Grik2 and KA2. Stimulation of Grik1 leads to intracellular calcium release and activation of protein kinase C. Excessive activation has been associated with psychiatric, neurological and neurodegenerative diseases. Numerous isoforms of Grik1 are known to exist and may be subject to RNA editing within the second transmembrane domain, which is thought to alter the properties of ion flow.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GluK1; GluR-5; glutamate receptor; Glutamate receptor 5; Glutamate receptor ionotropic, kainate 1
Gene Aliases: GluK1; GluR5; Grik1
UniProt ID: (Rat) P22756
Entrez Gene ID: (Rat) 29559
chemical synaptic transmission
nervous system development
positive regulation of gamma-aminobutyric acid secretion
adult behavior
negative regulation of synaptic transmission, GABAergic
positive regulation of synaptic transmission, GABAergic
ion transmembrane transport
regulation of ion transmembrane transport
ionotropic glutamate receptor signaling pathway
synaptic transmission, glutamatergic
regulation of membrane potential
regulation of synaptic plasticity
regulation of short-term neuronal synaptic plasticity
behavioral response to pain
membrane depolarization
negative regulation of synaptic transmission, glutamatergic
excitatory postsynaptic potential
inhibitory postsynaptic potential
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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