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Invitrogen
GRIK5 Polyclonal Antibody
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Product Details
PA5-20451
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A 17 amino acid peptide near the carboxy terminus of the human Grik5.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_11152167
Product Specific Information
A suggested positive control is human brain tissue lysate.
PA5-20451 can be used with blocking peptide PEP-0568.
Target Information
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. Grik5, also known as kainate-preferring glutamate recptor subunit KA2, belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. Grik5 is highly homologous to the related ionotrophic glutamate receptor Grik4 (also known as KA1). Like Grik4, Grik5 does not form homomeric channels, but instead forms heteromers with Grik2. In Grik2- but not Grik1-null mice, Grik5 surface expression is greatly reduced in neurons, indicating that Grik2/Grik5 heteromers are required for exit from the endoplasmic reticulum to the cell surface.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: EAA2; Excitatory amino acid receptor 2; GluK5; GluR gamma-2; glutamate receptor; Glutamate receptor gamma-2; Glutamate receptor ionotropic, kainate 5; Glutamate receptor KA-2; glutamate receptor KA2; glutamate receptor, ionotropic kainate 5; glutamate receptor, ionotropic, kainate 5; KA2
Gene Aliases: EAA2; GluK5; GluRgamma2; GRIK2; GRIK5; iGlu5; KA2
UniProt ID: (Human) Q16478, (Rat) Q63273, (Mouse) Q61626
Entrez Gene ID: (Human) 2901, (Rat) 24407, (Mouse) 14809
extracellular-glutamate-gated ion channel activity
ligand-gated ion channel activity
kainate selective glutamate receptor activity
SH3 domain binding
PDZ domain binding
identical protein binding
protein binding
glutamate receptor activity
receptor activity
ionotropic glutamate receptor activity
ion channel activity
protein retention in ER lumen
regulation of synaptic vesicle fusion to presynaptic membrane
ion transmembrane transport
ionotropic glutamate receptor signaling pathway
synaptic transmission, glutamatergic
receptor clustering
positive regulation of neuron apoptotic process
establishment of localization in cell
excitatory postsynaptic potential
cellular response to glucose stimulus
signal transduction
chemical synaptic transmission
regulation of membrane potential
transport
ion transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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