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Bioss
GRIM19 Polyclonal Antibody
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Product Details
BS-3594R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human GRIM19, amino acids 51-144.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
A novel gene associated with Retinoid-IFN-induced Mortality (GRIM) GRIM-19 gene was identified. Antisense expression of GRIM-19 confers a strong resistance against IFN/RA-induced death by reducing the intracellular levels of GRIM-19 protein. Overexpression of GRIM-19 enhances cell death in response to IFN/RA. GRIM-19 is primarily a nuclear protein whose expression is induced by the IFN/RA combination. These data indicate that GRIM-19 is a novel cell death-regulatory molecule.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cell d; Cell death regulatory protein GRIM-19; cell death-regulatory protein GRIM19; CI-B16.6; complex I B16.6 subunit; Complex I-B16.6; FLJ58045; FLJ59191; gene associated with retinoic and IFN-induced mortality 19 protein; Gene associated with retinoic and interferon-induced mortality 19 protein; gene associated with retinoic-interferon-induced mortality 19 protein; genes associated with retinoid-IFN-induced mortality 19; GRIM-19; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13; NADH-ubiquinone oxidoreductase B16.6 subunit
Gene Aliases: 2700054G14Rik; AU022060; B16.6; CDA016; CGI-39; GRIM-19; GRIM19; NDUFA13
UniProt ID: (Human) Q9P0J0, (Mouse) Q9ERS2
Entrez Gene ID: (Rat) 100911483, (Human) 51079, (Mouse) 67184
mitochondrial electron transport, NADH to ubiquinone
positive regulation of peptidase activity
negative regulation of cell growth
mitochondrial respiratory chain complex I assembly
cellular response to interferon-beta
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
protein import into mitochondrial inner membrane
positive regulation of protein catabolic process
negative regulation of transcription, DNA-templated
cellular response to retinoic acid
reactive oxygen species metabolic process
apoptotic signaling pathway
extrinsic apoptotic signaling pathway
negative regulation of intrinsic apoptotic signaling pathway
oxidation-reduction process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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