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          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • NMDAR2B Antibodies

          Abnova

          GRIN2B Monoclonal Antibody (2G5)

          View all (49) NMDAR2B antibodies

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          Datasheet
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          Datasheet
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          Cite GRIN2B Monoclonal Antibody (2G5)

          • Antibody Testing Data (2)
          GRIN2B Antibody in ELISA (ELISA)
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          GRIN2B Antibody in ELISA (ELISA)
          Group 53 Created with Sketch.

          FIGURE: 1 / 2

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          GRIN2B Antibody (H00002904-M01) in ELISA

          Detection limit for recombinant GST tagged GRIN2B is approximately 3 ng/mL as a capture antibody. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          GRIN2B Antibody in ELISA (ELISA)
          GRIN2B Antibody in Proximity Ligation Assay (PLA) (PLA)

          Product Details

          H00002904-M01

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1-5 µg/mL
          -

          ELISA (ELISA)

          3 ng/mL
          -

          in situ PLA (PLA)

          1:1200
          -
          Product Specifications

          Species Reactivity

          Human

          Host/Isotype

          Mouse / IgG2a, kappa

          Class

          Monoclonal

          Type

          Antibody

          Clone

          2G5

          Immunogen

          GRIN2B (NP_000825, 127 a.a. approximately 236 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
          View immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          See Label

          Purification

          Affinity chromatography

          Storage buffer

          PBS, pH 7.4

          Contains

          no preservative

          Storage conditions

          -20°C, Avoid Freeze/Thaw Cycles

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          Product Specific Information

          Sequence of this protein is as follows: HGGSSMIMAD KDESSMFFQF GPSIEQQASV MLNIMEEYDW YIFSIVTTYF PGYQDFVNKI RSTIENSFVG WELEEVLLLD MSLDDGDSKI QNQLKKLQSP IILLYCTKEE

          Target Information

          NMDAR2B is a member of the N-methyl-D-aspartate (NMDA) class of ionotropic glutamate receptors. NMDA receptors (NMDAR) have been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDAR play a role in neuronal development and has been implicated in several disorders of the central nervous system including Alzheimer’s Disease, epilepsy and ischemic neuronal cell death. Overexpression of the NR2B subunit of the receptor has been associated with increases in learning and memory while aged, memory impaired animals have deficiencies in NR2B expression. Tyr1472 on NR2B is phosphorylated and this may lead to the increased expression of the NMDAR at the synapse that plays a role in synaptic plasticity. NMDR2B is a heterotrimer comprised of seven enetically encoded and differentially expressed subunits that include NR1, NR2 and NR3. Diseases associated with the dysfunction of NMDAR2B include epileptic encephalopathy, autosomal dominant 6-related mental retardation.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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          Cite this product

          Bioinformatics

          Protein Aliases: GluN2B; Glutamate [NMDA] receptor subunit epsilon-2; glutamate receptor; Glutamate receptor ionotropic, NMDA 2B; glutamate receptor subunit epsilon-2; glutamate receptor, ionotropic, N-methyl D-aspartate 2B; GRIN 2B; HGNC:4586; hNR 3; MGC142178; MGC142180; N-methyl D-aspartate receptor subtype 2B; N-methyl-D-aspartate receptor subunit 3; NMDAR2B; NMDE2; NME2; NR3

          View more View less

          Gene Aliases: EIEE27; GluN2B; GRIN2B; hNR3; MRD6; NMDAR2B; NR2B

          View more View less

          UniProt ID: (Human) Q13224

          View more View less

          Entrez Gene ID: (Human) 2904

          View more View less

          Function(s)
          NMDA glutamate receptor activity Ras guanyl-nucleotide exchange factor activity extracellular-glutamate-gated ion channel activity protein binding zinc ion binding glycine binding
          Process(es)
          MAPK cascade transport glutamate receptor signaling pathway chemical synaptic transmission learning or memory ion transmembrane transport ionotropic glutamate receptor signaling pathway positive regulation of GTPase activity response to ethanol ephrin receptor signaling pathway
          It has to be done as per old AB suggested Products section.
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          If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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