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Invitrogen
GRK3 Polyclonal Antibody
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Product Details
PA5-102565
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human GRK3(Accession P35626), corresponding to amino acid residues S371-L421.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2851967
Product Specific Information
Antibody detects endogenous levels of total GRK3.
Target Information
ADRBK2, or adrenergic beta receptor kinase 2 is a serine/threonine kinase that is thought to act as a regulator of receptor function. Overall, the ADRBK2 enzyme, also known as GRK3, has 85% amino acid similarity with ADRBK1, with the protein kinase catalytic domain having 95% similarity. The ADRBK2 mRNA is approximately 8 kilobases with a distribution similar to that of ADRBK1. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: adrenergic receptor kinase, beta 2 (G-protein-linked receptor kinase); adrenergic, beta, receptor kinase 2; beta ARK2; Beta-adrenergic receptor kinase 2; Beta-ARK-2; G protein-coupled receptor kinase 3; G-protein-coupled receptor kinase 3
Gene Aliases: 4833444A01Rik; Adrbk-2; ADRBK2; AI851927; AW551196; Bark-2; BARK2; GRK3
UniProt ID: (Mouse) Q3UYH7, (Rat) P26819, (Human) P35626
Entrez Gene ID: (Mouse) 320129, (Rat) 25372, (Human) 157
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
G-protein coupled receptor kinase activity
ATP binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
D1 dopamine receptor binding
beta-adrenergic receptor kinase activity
positive regulation of protein phosphorylation
desensitization of G-protein coupled receptor protein signaling pathway
protein phosphorylation
intracellular protein transport
signal transduction
phosphorylation
receptor internalization
termination of G-protein coupled receptor signaling pathway
inositol phosphate metabolic process
rhodopsin metabolic process
multicellular organism aging
negative regulation of G-protein coupled receptor protein signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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