Proteintech

GRK5 Polyclonal Antibody

GRK5 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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GRK5 Antibody (17032-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human skeletal muscle tissue slide using 17032-1-AP ( GRK5 Antibody) at dilution of 1:200 (under 40x lens).

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Product Details

17032-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 3 publications 3 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

View 3 publications 3 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

GRK5 Fusion Protein Ag10511 (186-590 aa encoded by BC064506)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.28 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: FRQYRVLGK GGFGEVCACQ VRATGKMYAC KRLEKKRIKK RKGESMALNE KQILEKVNSQ FVVNLAYAYE TKDALCLVLT IMNGGDLKFH IYNMGNPGFE EERALFYAAE ILCGLEDLHR ENTVYRDLKP ENILLDDYGH IRISDLGLAV KIPEGDLIRG RVGTVGYMAP EVLNNQRYGL SPDYWGLGCL IYEMIEGQSP FRGRKEKVKR EEVDRRVLET EEVYSHKFSE EAKSICKMLL TKDAKQRLGC QEEGAAEVKR HPFFRNMNFK RLEAGMLDPP FVPDPRAVYC KDVLDIEQFS TVKGVNLDHT DDDFYSKFST GSVSIPWQNE MIETECFKEL NVFGPNGTLP PDLNRNHPPE PPKKGLLQRL FKRQHQNNSK SSPSSKTSFN HHINSNHVSS NSTGSS (186-590 aa encoded by BC064506)

Target Information

GRK5 is a serine/threonine kinase that regulates the activity of a variety of G protein-coupled receptors and the motility of polymorphonuclear leukocytes. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. It has also been shown to play a role in regulating the motility of polymorphonuclear leukocytes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Identification and validation of chemokine system-related genes in idiopathic pulmonary fibrosis.

Frontiers in immunology

Zhao T,Wu X,Zhao X,Yao K,Li X,Ni J

Tue May 02 00:00:00 UTC 2023

Genetic Arg-304-His substitution in GRK5 protects against sepsis progression by alleviating NF-κB-mediated inflammation.

International immunopharmacology

Xu M,Shao Y,Lin K,Liu Y,Lin Y,Lin Y,Yang R,Liu L,Yin M,Liao S,Jiang S,He J

Wed Feb 01 00:00:00 UTC 2023

METTL3-mediated m6A mRNA methylation regulates neutrophil activation through targeting TLR4 signaling.

Cell reports

Luo S,Liao C,Zhang L,Ling C,Zhang X,Xie P,Su G,Chen Z,Zhang L,Lai T,Tang J

Tue Mar 28 00:00:00 UTC 2023

Co-Overexpression of GRK5/ACTC1 Correlates With the Clinical Parameters and Poor Prognosis of Epithelial Ovarian Cancer.

Frontiers in molecular biosciences

Liu L,Lv J,Lin Z,Ning Y,Li J,Liu P,Chen C

Tue Mar 01 00:00:00 UTC 2022

G protein-coupled receptor kinase 5 deletion suppresses synovial inflammation in a murine model of collagen antibody-induced arthritis.

Scientific reports

Toya M,Akasaki Y,Sueishi T,Kurakazu I,Kuwahara M,Uchida T,Tsutsui T,Tsushima H,Yamada H,Lotz MK,Nakashima Y

Tue May 18 00:00:00 UTC 2021

G protein-coupled receptor kinase 5 deletion suppresses synovial inflammation in a murine model of collagen antibody-induced arthritis.

Scientific reports

Toya M,Akasaki Y,Sueishi T,Kurakazu I,Kuwahara M,Uchida T,Tsutsui T,Tsushima H,Yamada H,Lotz MK,Nakashima Y

Tue May 18 00:00:00 UTC 2021

GRK5 Inhibition Attenuates Cartilage Degradation via Decreased NF-κB Signaling.

Arthritis & rheumatology (Hoboken, N.J.)

Sueishi T,Akasaki Y,Goto N,Kurakazu I,Toya M,Kuwahara M,Uchida T,Hayashida M,Tsushima H,Bekki H,Lotz MK,Nakashima Y

Wed Apr 01 00:00:00 UTC 2020

GRK5 Inhibition Attenuates Cartilage Degradation via Decreased NF-κB Signaling.

Arthritis & rheumatology (Hoboken, N.J.)

Sueishi T,Akasaki Y,Goto N,Kurakazu I,Toya M,Kuwahara M,Uchida T,Hayashida M,Tsushima H,Bekki H,Lotz MK,Nakashima Y

Wed Apr 01 00:00:00 UTC 2020

GRK5 Inhibition Attenuates Cartilage Degradation via Decreased NF-κB Signaling.

Arthritis & rheumatology (Hoboken, N.J.)

Sueishi T,Akasaki Y,Goto N,Kurakazu I,Toya M,Kuwahara M,Uchida T,Hayashida M,Tsushima H,Bekki H,Lotz MK,Nakashima Y

Wed Apr 01 00:00:00 UTC 2020

GRK5 Inhibition Attenuates Cartilage Degradation via Decreased NF-κB Signaling.

Arthritis & rheumatology (Hoboken, N.J.)

Sueishi T,Akasaki Y,Goto N,Kurakazu I,Toya M,Kuwahara M,Uchida T,Hayashida M,Tsushima H,Bekki H,Lotz MK,Nakashima Y

Wed Apr 01 00:00:00 UTC 2020

Ligand-dependent internalization of Bombyx mori tachykinin-related peptide receptor is regulated by PKC, GRK5 and β-arrestin2/BmKurtz.

Biochimica et biophysica acta. Molecular cell research

He X,Yan L,Wu Q,Zhang G,Zhou N

Mon Jun 01 00:00:00 UTC 2020

Bioinformatics

Protein Aliases: Alpha-CP4; FP2025; G protein-coupled receptor kinase 5; G protein-coupled receptor kinase GRK5; GRK; GRK-pan; Pan-GRK; Poly(rC)-binding protein 4

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Gene Aliases: 1200003L19Rik; AlphaCP-4; GPRK5; GRK5; Pcbp4

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UniProt ID: (Human) P34947, (Mouse) Q8VEB1, (Rat) Q62833, (Mouse) P57724

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Entrez Gene ID: (Human) 2869, (Mouse) 14773, (Rat) 59075, (Mouse) 59092

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Function(s)

protein serine/threonine kinase activity G-protein coupled receptor kinase activity protein kinase C binding protein binding ATP binding phospholipid binding beta-adrenergic receptor kinase activity nucleotide binding protein kinase activity lipid binding kinase activity transferase activity transferase activity, transferring phosphorus-containing groups nucleic acid binding DNA binding RNA binding poly(A) RNA binding

Process(es)

negative regulation of mRNA splicing, via spliceosome desensitization of G-protein coupled receptor protein signaling pathway apoptotic process adenylate cyclase-modulating G-protein coupled receptor signaling pathway tachykinin receptor signaling pathway regulation of G-protein coupled receptor protein signaling pathway positive regulation of cell proliferation Wnt signaling pathway response to drug negative regulation of apoptotic process fat cell differentiation protein autophosphorylation regulation of cell cycle protein phosphorylation signal transduction phosphorylation termination of G-protein coupled receptor signaling pathway

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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GRK5 Polyclonal Antibody

GRK5 Antibody (17032-1-AP) in IHC (P)

Product Details

17032-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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