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Product Details
H00002915-M07
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b, kappa
Class
Monoclonal
Type
Antibody
Clone
3E7
Immunogen
GRM5 (NP_000833, 419 a.a. approximately 518 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
See Label
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: CPGYAGLCDA MKPIDGRKLL ESLMKTNFTG VSGDTILFDE NGDSPGRYEI MNFKEMGKDY FDYINVGSWD NGELKMDDDE VWSKKSNIIR SVCSEPCEKG
Target Information
GRK1 is a member of the guanine nucleotide protein-coupled (G protein) receptor kinase subfamily of Serine/Threonine kinase family. GRK1 phosphorylates rhodopsin and initiates its deactivation. G protein mediated phosphorylation promotes the binding of arrestin, which removes the receptor from the G-protein and terminates the receptor signal chain. GRK1 is farnesylated to promote membrane association. Studies have shown that GRK1 has been shown to be inhibited by recoverin, a Calcium binding protein. Diseases associated with GRK1 protein dysfunction include Oguchi Disease-2 and Hereditary Night Blindness.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: A830007B11Rik; D16Ium24; D16Ium24e; Glur-5; Glur5; Glurbeta1; glutamate receptor; glutamate receptor, metabotropic 5; GPRC1A; GRM 1; GRM 5; GRM1; GRM1 alpha; GRM1A; metabotropic 1; Metabotropic glutamate receptor 5; MGC25101; mGlu1; mGluR; mGluR1; mGluR1 alpha; mGluR1A; mGluR5; mGluR5a; protein phosphatase 1, regulatory subunit 86
Gene Aliases: GPRC1E; GRM5; mGlu5; MGLUR5; PPP1R86
UniProt ID: (Human) P41594
Entrez Gene ID: (Human) 2915
protein kinase C-activating G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled glutamate receptor signaling pathway
G-protein coupled glutamate receptor signaling pathway
chemical synaptic transmission
learning
locomotory behavior
regulation of long-term neuronal synaptic plasticity
cognition
regulation of synaptic transmission, glutamatergic
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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