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Proteintech
GRM8 Polyclonal Antibody
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Product Details
18224-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
GRM8 Fusion Protein Ag13011 (31-400 aa encoded by BC093725)
Conjugate
Form
Liquid
Concentration
0.37 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: THSQEYAHS IRVDGDIILG GLFPVHAKGE RGVPCGELKK EKGIHRLEAM LYAIDQINKD PDLLSNITLG VRILDTCSRD TYALEQSLTF VQALIEKDAS DVKCANGDPP IFTKPDKISG VIGAAASSVS IMVANILRLF KIPQISYAST APELSDNTRY DFFSRVVPPD SYQAQAMVDI VTALGWNYVS TLASEGNYGE SGVEAFTQIS REIGGVCIAQ SQKIPREPRP GEFEKIIKRL LETPNARAVI MFANEDDIRR ILEAAKKLNQ SGHFLWIGSD SWGSKIAPVY QQEEIAEGAV TILPKRASID GFDRYFRSRT LANNRRNVWF AEFWEENFGC KLGSHGKRNS HIKKCTGLER IARDSSYEQE G (31-400 aa encoded by BC093725)
Target Information
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: FLJ41058; G protein coupled receptor, family C, group 1, member H; G protein-coupled receptor family C group 1 member H; G protein-coupled receptor, family C, group 1, member H; glutamate receptor; glutamate receptor, metabotropic 8; M mGlu8; Metabotropic glutamate receptor 8; metabotropic glutamate receptor subtype 8b; MGC126724; mGluR8
Gene Aliases: A230002O04; GLUR8; GPRC1H; GRM8; mGlu8; mGlur; MGLUR8; mGluR8b
UniProt ID: (Human) O00222, (Rat) P70579, (Mouse) P47743
Entrez Gene ID: (Human) 2918, (Rat) 60590, (Mouse) 14823
adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway
visual perception
sensory perception of smell
negative regulation of cAMP biosynthetic process
regulation of synaptic transmission, glutamatergic
G-protein coupled receptor signaling pathway
chemical synaptic transmission
sensory perception of pain
synaptic transmission, glutamatergic
regulation of neurotransmitter secretion
detection of mechanical stimulus involved in sensory perception of pain
regulation of neuron death
signal transduction
response to stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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