Proteintech

GSTA1 Polyclonal Antibody

GSTA1 Antibody in Immunocytochemistry (ICC/IF)

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GSTA1 Antibody (14475-1-AP) in ICC/IF

Immunofluorescent analysis of HepG2 cells, using GSTA1 antibody 14475-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IGG (red).

GSTA1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

GSTA1 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

14475-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:4,000

View 13 publications 13 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:800

Immunocytochemistry (ICC/IF)

1:10-1:100

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

GSTA1 Fusion Protein Ag5849 (1-222 aa encoded by BC053578)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.3 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MAEKPKLHY FNARGRMEST RWLLAAAGVE FEEKFIKSAE DLDKLRNDGY LMFQQVPMVE IDGMKLVQTR AILNYIASKY NLYGKDIKER ALIDMYIEGI ADLGEMILLL PVCPPEEKDA KLALIKEKIK NRYFPAFEKV LKSHGQDYLV GNKLSRADIH LVELLYYVEE LDSSLISSFP LLKALKTRIS NLPTVKKFLQ PGSPRKPPMD EKSLEEARKI FRF (1-222 aa encoded by BC053578)

Target Information

This gene encodes a member of a family of enzymes that function to add glutathione to target electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins, and products of oxidative stress. This action is an important step in detoxification of these compounds. This subfamily of enzymes has a particular role in protecting cells from reactive oxygen species and the products of peroxidation. Polymorphisms in this gene influence the ability of individuals to metabolize different drugs. This gene is located in a cluster of similar genes and pseudogenes on chromosome 6. Alternative splicing results in multiple transcript variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Pregnane X receptor agonist nomilin extends lifespan and healthspan in preclinical models through detoxification functions.

Nature communications

Fan S,Yan Y,Xia Y,Zhou Z,Luo L,Zhu M,Han Y,Yao D,Zhang L,Fang M,Peng L,Yu J,Liu Y,Gao X,Guan H,Li H,Wang C,Wu X,Zhu H,Cao Y,Huang C

Thu Jun 08 00:00:00 UTC 2023

Rice protein suppresses 4-hydroxy-2-nonenal-induced inflammation owing to methionine availability.

Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme

Wang Z,Liang M,Li H,Liu B,Yang L

Mon Aug 01 00:00:00 UTC 2022

Tubular IKKβ Deletion Alleviates Acute Ischemic Kidney Injury and Facilitates Tissue Regeneration.

International journal of molecular sciences

Dahlke E,Engmann T,Anan Y,Häsler R,Solinas G,Theilig F

Mon Sep 05 00:00:00 UTC 2022

Tubular IKKβ Deletion Alleviates Acute Ischemic Kidney Injury and Facilitates Tissue Regeneration.

International journal of molecular sciences

Dahlke E,Engmann T,Anan Y,Häsler R,Solinas G,Theilig F

Mon Sep 05 00:00:00 UTC 2022

Heat-Not-Burn cigarette induces oxidative stress response in primary rat alveolar epithelial cells.

PloS one

Ito Y,Oshinden K,Kutsuzawa N,Kohno C,Isaki S,Yokoyama K,Sato T,Tanaka M,Asano K

Fri Jan 08 00:00:00 UTC 2021

Rice protein stimulates endogenous antioxidant response attributed to methionine availability in growing rats.

Journal of food biochemistry

Wang Z,Cai L,Li H,Liang M,Zhang Y,Wu Q,Yang L

Fri May 01 00:00:00 UTC 2020

Rice Protein Exerts Endogenous Antioxidant Capacity via Methionine Sulfoxide Reductase and the Nrf2 Antioxidant System Independent of Age.

Journal of medicinal food

Li H,Liang M,Wang Z,Zhang Y,Wu Q,Yang L

Mon Jun 01 00:00:00 UTC 2020

l-Methionine activates Nrf2-ARE pathway to induce endogenous antioxidant activity for depressing ROS-derived oxidative stress in growing rats.

Journal of the science of food and agriculture

Wang Z,Liang M,Li H,Cai L,He H,Wu Q,Yang L

Thu Aug 15 00:00:00 UTC 2019

γ-Oryzanol Improves Cognitive Function and Modulates Hippocampal Proteome in Mice.

Nutrients

Rungratanawanich W,Cenini G,Mastinu A,Sylvester M,Wilkening A,Abate G,Bonini SA,Aria F,Marziano M,Maccarinelli G,Memo M,Voos W,Uberti D

Sun Mar 31 00:00:00 UTC 2019

l-Arginine induces antioxidant response to prevent oxidative stress via stimulation of glutathione synthesis and activation of Nrf2 pathway.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Liang M,Wang Z,Li H,Cai L,Pan J,He H,Wu Q,Tang Y,Ma J,Yang L

Tue May 01 00:00:00 UTC 2018

l-Arginine induces antioxidant response to prevent oxidative stress via stimulation of glutathione synthesis and activation of Nrf2 pathway.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Liang M,Wang Z,Li H,Cai L,Pan J,He H,Wu Q,Tang Y,Ma J,Yang L

Tue May 01 00:00:00 UTC 2018

Poly(ADP-ribosyl)ated PXR is a critical regulator of acetaminophen-induced hepatotoxicity.

Cell death & disease

Wang C,Xu W,Zhang Y,Huang D,Huang K

Thu Jul 26 00:00:00 UTC 2018

Poly(ADP-ribosyl)ated PXR is a critical regulator of acetaminophen-induced hepatotoxicity.

Cell death & disease

Wang C,Xu W,Zhang Y,Huang D,Huang K

Thu Jul 26 00:00:00 UTC 2018

Growth hormone alters the glutathione S-transferase and mitochondrial thioredoxin systems in long-living Ames dwarf mice.

The journals of gerontology. Series A, Biological sciences and medical sciences

Rojanathammanee L,Rakoczy S,Brown-Borg HM

Wed Oct 01 00:00:00 UTC 2014

Growth hormone alters the glutathione S-transferase and mitochondrial thioredoxin systems in long-living Ames dwarf mice.

The journals of gerontology. Series A, Biological sciences and medical sciences

Rojanathammanee L,Rakoczy S,Brown-Borg HM

Wed Oct 01 00:00:00 UTC 2014

Effects of insulin-like growth factor 1 on glutathione S-transferases and thioredoxin in growth hormone receptor knockout mice.

Age (Dordrecht, Netherlands)

Rojanathammanee L,Rakoczy S,Kopchick J,Brown-Borg HM

Tue Mar 31 00:00:00 UTC 2015

Effects of insulin-like growth factor 1 on glutathione S-transferases and thioredoxin in growth hormone receptor knockout mice.

Age (Dordrecht, Netherlands)

Rojanathammanee L,Rakoczy S,Kopchick J,Brown-Borg HM

Tue Mar 31 00:00:00 UTC 2015

Thioacetamide-induced Hepatocellular Necrosis Is Attenuated in Diet-induced Obese Mice.

Journal of toxicologic pathology

Shirai M,Arakawa S,Miida H,Matsuyama T,Kinoshita J,Makino T,Kai K,Teranishi M

Sat Jun 01 00:00:00 UTC 2013

Thioacetamide-induced Hepatocellular Necrosis Is Attenuated in Diet-induced Obese Mice.

Journal of toxicologic pathology

Shirai M,Arakawa S,Miida H,Matsuyama T,Kinoshita J,Makino T,Kai K,Teranishi M

Sat Jun 01 00:00:00 UTC 2013

Bioinformatics

Protein Aliases: 13-hydroperoxyoctadecadienoate peroxidase; Androst-5-ene-3,17-dione isomerase; class alpha; glutathione S-alkyltransferase A1; glutathione S-aryltransferase A1; glutathione S-transferase 2; Glutathione S-transferase A1; glutathione S-transferase A3 subunit; glutathione S-transferase A5; Glutathione S-transferase alpha-3; glutathione S-transferase Ha subunit 1; Glutathione S-transferase Ya; Glutathione S-transferase Ya1; Glutathione S-transferase Yc-1; glutathione S-transferase Yc1 subunit; Glutathione-S-transferase alpha type (Ya); GST; GST 2-2; GST A3-3; GST AA; GST class-alpha member 1; GST HA subunit 1; GST Yc1; GST-epsilon; GSTA1-1; GTH1; RP11-392A23.1; S-(hydroxyalkyl)glutathione lyase A1; testicular tissue protein Li 80

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Gene Aliases: GST-epsilon; GST2; Gst2-1; Gsta; GSTA1; GSTA1-1; Gsta3; Gsta5; Gstya; Gstyc1; GTH1; OTTMUSG00000031890; Yc1

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UniProt ID: (Human) P08263, (Rat) P04904, (Mouse) P13745

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Entrez Gene ID: (Human) 2938, (Rat) 24421, (Mouse) 14857

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Function(s)

glutathione transferase activity glutathione peroxidase activity drug binding glutathione binding

Process(es)

glutathione metabolic process metabolic process epithelial cell differentiation linoleic acid metabolic process cellular oxidant detoxification glutathione derivative biosynthetic process aging response to nutrient levels xenobiotic catabolic process response to drug

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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GSTA1 Polyclonal Antibody

GSTA1 Antibody (14475-1-AP) in ICC/IF

Product Details

14475-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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