Proteintech

GSTM1 Polyclonal Antibody

GSTM1 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 8

GSTM1 Antibody (12412-1-AP) in ICC/IF

Immunofluorescent analysis of ( -20°C Ethanol ) fixed HeLa cells using 12412-1-AP (GSTM1 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

GSTM1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Product Image Gallery

Product Details

12412-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 14 publications 14 publications

Immunohistochemistry (IHC)

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

1:50-1:500

View 2 publications 2 publications

Miscellaneous PubMed (MISC)

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

GSTM1 Fusion Protein Ag3113 (1-181 aa encoded by BC024005)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MPMILGYWD IRGLAHAIRL LLEYTDSSYE EKKYTMGDAP DYDRSQWLNE KFKLGLDFPN LPYLIDGAHK ITQSNAILCY IARKHNLCGE TEEEKIRVDI LENQTMDNHM QLGMICYNPE FEKLKPKYLE ELPEKLKLYS EFLGKRPWFA GNKGLEKISA YMKSSRFLPR PVFSKMAVWG NK (1-181 aa encoded by BC024005)

Target Information

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13. 3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Quantitative Proteomics Identifies Novel Nrf2-Mediated Adaptative Signaling Pathways in Skeletal Muscle Following Exercise Training.

Antioxidants (Basel, Switzerland)

Bhat A,Abu R,Jagadesan S,Vellichirammal NN,Pendyala VV,Yu L,Rudebush TL,Guda C,Zucker IH,Kumar V,Gao L

Mon Jan 09 00:00:00 UTC 2023

Role of Nrf2 in 1,2-dichloropropane-induced cell proliferation and DNA damage in the mouse liver.

Toxicological sciences : an official journal of the Society of Toxicology

Kimura Y,Ekuban FA,Zong C,Sugie S,Zhang X,Itoh K,Yamamoto M,Ichihara S,Ohsako S,Ichihara G

Tue Aug 29 00:00:00 UTC 2023

Dominant-acting CSF1R variants cause microglial depletion and altered astrocytic phenotype in zebrafish and adult-onset leukodystrophy.

Acta neuropathologica

Berdowski WM,van der Linde HC,Breur M,Oosterhof N,Beerepoot S,Sanderson L,Wijnands LI,de Jong P,Tsai-Meu-Chong E,de Valk W,de Witte M,van IJcken WFJ,Demmers J,van der Knaap MS,Bugiani M,Wolf NI,van Ham TJ

Mon Aug 01 00:00:00 UTC 2022

lncRNA-GM targets Foxo1 to promote T cell-mediated autoimmunity.

Science advances

Chen Y,Liu J,Zhang X,Zhu H,Wang Y,Li Z,Liu Y,Liu S,Liu S,Li N,Chen K,Cao X

Fri Aug 05 00:00:00 UTC 2022

Gstm1/Gstt1 is essential for reducing cisplatin ototoxicity in CBA/CaJ mice.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Li P,Liu Z,Wang J,Bi X,Xiao Y,Qiao R,Zhou X,Guo S,Wan P,Chang M,Hong G,Liu Z,Ming X,Gao J,Fu X

Wed Jun 01 00:00:00 UTC 2022

Identification of Key Differentially Methylated/Expressed Genes and Pathways for Ovarian Endometriosis by Bioinformatics Analysis.

Reproductive sciences (Thousand Oaks, Calif.)

Zhang H,Wu J,Li Y,Jin G,Tian Y,Kang S

Sun May 01 00:00:00 UTC 2022

Establishment and characterization of a new cell culture system for hepatitis B virus replication and infection.

Virologica Sinica

Song Y,Shou S,Guo H,Gao Z,Liu N,Yang Y,Wang F,Deng Q,Liu J,Xie Y

Mon Aug 01 00:00:00 UTC 2022

Glutathione S-transferases Control astrocyte activation and neuronal health during neuroinflammation.

Frontiers in molecular biosciences

Matoba K,Dohi E,Choi EY,Kano SI

Wed Sep 11 00:00:00 UTC 2024

Glutathione S-transferases Control astrocyte activation and neuronal health during neuroinflammation.

Frontiers in molecular biosciences

Matoba K,Dohi E,Choi EY,Kano SI

Wed Sep 11 00:00:00 UTC 2024

Guanxin Xiaoban capsules could treat atherosclerosis by affecting the gut microbiome and inhibiting the AGE-RAGE signalling pathway.

Journal of medical microbiology

Dongliang Y,Yang R,Peng S,Deng J,Huo Y,Deng Z,Yau Y,Liu J,Liao D,Cheng C

Sun May 01 00:00:00 UTC 2022

A distinct astrocyte subtype in the aging mouse brain characterized by impaired protein homeostasis.

Nature aging

Lee E,Jung YJ,Park YR,Lim S,Choi YJ,Lee SY,Kim CH,Mun JY,Chung WS

Mon Aug 01 00:00:00 UTC 2022

Nrf2 expression in pancreatic stellate cells promotes progression of cancer.

American journal of physiology. Gastrointestinal and liver physiology

Tanaka Y,Hamada S,Matsumoto R,Taguchi K,Yamamoto M,Masamune A

Fri Oct 01 00:00:00 UTC 2021

Wogonin alleviates liver injury in sepsis through Nrf2-mediated NF-κB signalling suppression.

Journal of cellular and molecular medicine

Dai JM,Guo WN,Tan YZ,Niu KW,Zhang JJ,Liu CL,Yang XM,Tao KS,Chen ZN,Dai JY

Tue Jun 01 00:00:00 UTC 2021

Activation of PPARα-catalase pathway reverses alcoholic liver injury via upregulating NAD synthesis and accelerating alcohol clearance.

Free radical biology & medicine

Yue R,Chen GY,Xie G,Hao L,Guo W,Sun X,Jia W,Zhang Q,Zhou Z,Zhong W

Fri Oct 01 00:00:00 UTC 2021

ALS-FTLD-linked mutations of SQSTM1/p62 disrupt selective autophagy and NFE2L2/NRF2 anti-oxidative stress pathway.

Autophagy

Deng Z,Lim J,Wang Q,Purtell K,Wu S,Palomo GM,Tan H,Manfredi G,Zhao Y,Peng J,Hu B,Chen S,Yue Z

Fri May 01 00:00:00 UTC 2020

Decreased Expression of the Host Long-Noncoding RNA-GM Facilitates Viral Escape by Inhibiting the Kinase activity TBK1 via S-glutathionylation.

Immunity

Wang Y,Wang P,Zhang Y,Xu J,Li Z,Li Z,Zhou Z,Liu L,Cao X

Tue Dec 15 00:00:00 UTC 2020

A physiological concentration of luteolin induces phase II drug-metabolizing enzymes through the ERK1/2 signaling pathway in HepG2 cells.

Archives of biochemistry and biophysics

Kitakaze T,Makiyama A,Samukawa Y,Jiang S,Yamashita Y,Ashida H

Fri Mar 15 00:00:00 UTC 2019

A physiological concentration of luteolin induces phase II drug-metabolizing enzymes through the ERK1/2 signaling pathway in HepG2 cells.

Archives of biochemistry and biophysics

Kitakaze T,Makiyama A,Samukawa Y,Jiang S,Yamashita Y,Ashida H

Fri Mar 15 00:00:00 UTC 2019

Glutathione S-transferases promote proinflammatory astrocyte-microglia communication during brain inflammation.

Science signaling

Kano SI,Choi EY,Dohi E,Agarwal S,Chang DJ,Wilson AM,Lo BD,Rose IVL,Gonzalez S,Imai T,Sawa A

Tue Feb 19 00:00:00 UTC 2019

Glutathione S-transferases promote proinflammatory astrocyte-microglia communication during brain inflammation.

Science signaling

Kano SI,Choi EY,Dohi E,Agarwal S,Chang DJ,Wilson AM,Lo BD,Rose IVL,Gonzalez S,Imai T,Sawa A

Tue Feb 19 00:00:00 UTC 2019

Glutathione-S-transferases and Chemotherapy Resistance of Hodgkin's Lymphoma Cell Lines.

Anticancer research

Bernig T,Ritz S,Brodt G,Volkmer I,Staege MS

Mon Aug 01 00:00:00 UTC 2016

Glutathione-S-transferases and Chemotherapy Resistance of Hodgkin's Lymphoma Cell Lines.

Anticancer research

Bernig T,Ritz S,Brodt G,Volkmer I,Staege MS

Mon Aug 01 00:00:00 UTC 2016

Thioacetamide-induced Hepatocellular Necrosis Is Attenuated in Diet-induced Obese Mice.

Journal of toxicologic pathology

Shirai M,Arakawa S,Miida H,Matsuyama T,Kinoshita J,Makino T,Kai K,Teranishi M

Sat Jun 01 00:00:00 UTC 2013

Thioacetamide-induced Hepatocellular Necrosis Is Attenuated in Diet-induced Obese Mice.

Journal of toxicologic pathology

Shirai M,Arakawa S,Miida H,Matsuyama T,Kinoshita J,Makino T,Kai K,Teranishi M

Sat Jun 01 00:00:00 UTC 2013

Bioinformatics

Protein Aliases: glutathione S-alkyltransferase; glutathione S-aralkyltransferase; glutathione S-aryltransferase; Glutathione S-transferase GT8.7; glutathione S-transferase M1; Glutathione S-transferase Mu 1; Glutathione S-transferase Yb-1; glutathione S-transferase Yb-1 subunit; glutathione-S-transferase mu type 1 (Yb1); glutathione-S-transferase, mu 1; glutathione-S-transferase, mu type 1 (Yb1); GST 1-1; GST 3-3; GST class-mu 1; GST HB subunit 4; GST Yb1; GSTM1-1; GSTM1a-1a; GSTM1b-1b; GTH4; HB subunit 4; pmGT10; S-(hydroxyalkyl)glutathione lyase

View more View less

Gene Aliases: GST1; GSTA3; Gstb-1; Gstb1; GSTM1; GSTM1-1; GSTM1a-1a; GSTM1b-1b; GTH4; GTM1; H-B; MU; MU-1

View more View less

UniProt ID: (Human) P09488, (Mouse) P10649, (Rat) P04905

View more View less

Entrez Gene ID: (Human) 2944, (Mouse) 14862, (Rat) 24423

View more View less

Function(s)

glutathione transferase activity enzyme binding protein homodimerization activity glutathione binding steroid binding protein binding nickel cation binding transferase activity protein heterodimerization activity

Process(es)

glutathione metabolic process metabolic process cellular response to drug sensory perception of smell response to metal ion response to lithium ion response to lead ion nitrobenzene metabolic process xenobiotic catabolic process response to drug response to amino acid response to ethanol response to antibiotic response to axon injury cellular detoxification of nitrogen compound glutathione derivative biosynthetic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more

GSTM1 Polyclonal Antibody

GSTM1 Antibody (12412-1-AP) in ICC/IF

Product Details

12412-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Miscellaneous PubMed (MISC)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

We're here to help

Your items have has been added!