Proteintech

GSTP1 Polyclonal Antibody

GSTP1 Antibody in Immunocytochemistry (ICC/IF)

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GSTP1 Antibody (15902-1-AP) in ICC/IF

Immunofluorescent analysis of HepG2 cells using 15902-1-AP (GSTP1 Antibody) at dilution of 1:50 and Rhodamine-labeled goat anti-rabbit IGG (red).

GSTP1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

GSTP1 Antibody in Immunoprecipitation (IP)

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Product Details

15902-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 19 publications 19 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:20-1:200

View 4 publications 4 publications

Flow Cytometry (Flow)

0.2 µg/1x10^6 cells

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

GSTP1 Fusion Protein Ag8731 (1-210 aa encoded by BC010915)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.23 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MPPYTVVYF PVRGRCAALR MLLADQGQSW KEEVVTVETW QEGSLKASCL YGQLPKFQDG DLTLYQSNTI LRHLGRTLGL YGKDQQEAAL VDMVNDGVED LRCKYVSLIY TNYEAGKDDY VKALPGQLKP FETLLSQNQG GKTFIVGDQI SFADYNLLDL LLIHEVLAPG CLDAFPLLSA YVGRLSARPK LKAFLASPEY VNLPINGNGK Q (1-210 aa encoded by BC010915)

Target Information

Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. This GST family member is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Combination with vorinostat enhances the antitumor activity of cisplatin in castration-resistant prostate cancer by inhibiting DNA damage repair pathway and detoxification of GSH.

The Prostate

Chang T,Lian Z,Ma S,Liang Z,Ma X,Wen X,Wang Y,Liu R

Sat Apr 01 00:00:00 UTC 2023

RNA-binding protein SPEN controls hepatocyte maturation via regulating Hnf4α expression during liver development.

Biochemical and biophysical research communications

Zhang J,Yang Z,Yan X,Duan J,Ruan B,Zhang X,Wen T,Zhang P,Liang L,Han H

Sun Jan 29 00:00:00 UTC 2023

Ginsenoside Rg1 protects cardiac mitochondrial function via targeting GSTP1 to block S-glutathionylation of optic atrophy 1.

Free radical biology & medicine

Zhu H,Yan C,Yao P,Li P,Li Y,Yang H

Tue Aug 01 00:00:00 UTC 2023

GSTP1-mediated S-glutathionylation of Pik3r1 is a redox hub that inhibits osteoclastogenesis through regulating autophagic flux.

Redox biology

Ji X,Hong J,Yang W,Yao M,Wang J,Jiang G,Wang Y,Li C,Lin J,Mou H,Li C,Li S,Chen Y,Shi M,Wang W,Lu F,Wu H,Zhao X,Qi Y,Yan S

Mon May 01 00:00:00 UTC 2023

Study of Drug Resistance in Chemotherapy Induced by Extracellular Vesicles on a Microchip.

Analytical chemistry

Fang T,Lu W,Zhang J,Ge K,Chen Z,Wang M,Yao B

Tue Dec 06 00:00:00 UTC 2022

Comparative Analysis of Proteomic of Curcumin Reversing Multidrug Resistance in HCT-8/VCR Cells.

Journal of oncology

Li L,Yu L,Cao X,Zhang C,Liu Q,Chen J

Sat Jul 16 00:00:00 UTC 2022

COPS5 Conferred the Platinum Resistance in Epithelial Ovarian Cancer.

Current issues in molecular biology

Zhang H,Yan T,Zhong A,Guo L,Lu R

Thu Sep 01 00:00:00 UTC 2022

Nephrotoxicity evaluation of 3-monochloropropane-1,2-diol exposure in Sprague-Dawley rats using data-independent acquisition-based quantitative proteomics analysis.

Toxicology letters

Jin C,Min F,Zhong Y,Sun D,Luo R,Liu Q,Peng X

Tue Mar 01 00:00:00 UTC 2022

TDP-43 mediates SREBF2-regulated gene expression required for oligodendrocyte myelination.

The Journal of cell biology

Ho WY,Chang JC,Lim K,Cazenave-Gassiot A,Nguyen AT,Foo JC,Muralidharan S,Viera-Ortiz A,Ong SJM,Hor JH,Agrawal I,Hoon S,Arogundade OA,Rodriguez MJ,Lim SM,Kim SH,Ravits J,Ng SY,Wenk MR,Lee EB,Tucker-Kellogg G,Ling SC

Mon Sep 06 00:00:00 UTC 2021

Glutathione S-transferase Pi (Gstp) proteins regulate neuritogenesis in the developing cerebral cortex.

Human molecular genetics

Liu X,Blazejewski SM,Bennison SA,Toyo-Oka K

Thu Mar 25 00:00:00 UTC 2021

Glutathione S-transferase Pi (Gstp) proteins regulate neuritogenesis in the developing cerebral cortex.

Human molecular genetics

Liu X,Blazejewski SM,Bennison SA,Toyo-Oka K

Thu Mar 25 00:00:00 UTC 2021

Short hairpin RNA attenuates liver fibrosis by regulating the PPAR‑γ and NF‑κB pathways in HBV‑induced liver fibrosis in mice.

International journal of oncology

Ye L,Chen T,Cao J,Sun L,Li W,Zhang C

Sun Nov 01 00:00:00 UTC 2020

In Vitro and in Vivo Efficacy of NBDHEX on Gefitinib-resistant Human Non-small Cell Lung Cancer.

Journal of Cancer

Sha H,Dong S,Yu C,Zou R,Zhu Y,Lu Y,Zhang J,Cao H,Chen D,Wu J,Feng J

Tue Nov 17 00:00:00 UTC 2020

Protein target identification and toxicological mechanism investigation of silver nanoparticles-induced hepatotoxicity by integrating proteomic and metallomic strategies.

Particle and fibre toxicology

Xu M,Yang Q,Xu L,Rao Z,Cao D,Gao M,Liu S

Wed Nov 27 00:00:00 UTC 2019

Poly(ADP-ribosyl)ated PXR is a critical regulator of acetaminophen-induced hepatotoxicity.

Cell death & disease

Wang C,Xu W,Zhang Y,Huang D,Huang K

Thu Jul 26 00:00:00 UTC 2018

Poly(ADP-ribosyl)ated PXR is a critical regulator of acetaminophen-induced hepatotoxicity.

Cell death & disease

Wang C,Xu W,Zhang Y,Huang D,Huang K

Thu Jul 26 00:00:00 UTC 2018

Prognostic significance of GSTP1 in patients with triple negative breast cancer.

Oncotarget

Chen G,Zhang H,Sun L,Jiang Y,Xu Z,Gu H,Xu H,Yang J,Wang Y,Xu T,Zhang Y,Liu C

Fri Sep 15 00:00:00 UTC 2017

Prognostic significance of GSTP1 in patients with triple negative breast cancer.

Oncotarget

Chen G,Zhang H,Sun L,Jiang Y,Xu Z,Gu H,Xu H,Yang J,Wang Y,Xu T,Zhang Y,Liu C

Fri Sep 15 00:00:00 UTC 2017

The Essential Role of H19 Contributing to Cisplatin Resistance by Regulating Glutathione Metabolism in High-Grade Serous Ovarian Cancer.

Scientific reports

Zheng ZG,Xu H,Suo SS,Xu XL,Ni MW,Gu LH,Chen W,Wang LY,Zhao Y,Tian B,Hua YJ

Thu May 19 00:00:00 UTC 2016

The Essential Role of H19 Contributing to Cisplatin Resistance by Regulating Glutathione Metabolism in High-Grade Serous Ovarian Cancer.

Scientific reports

Zheng ZG,Xu H,Suo SS,Xu XL,Ni MW,Gu LH,Chen W,Wang LY,Zhao Y,Tian B,Hua YJ

Thu May 19 00:00:00 UTC 2016

Glutathione S-transferase P protects against cyclophosphamide-induced cardiotoxicity in mice.

Toxicology and applied pharmacology

Conklin DJ,Haberzettl P,Jagatheesan G,Baba S,Merchant ML,Prough RA,Williams JD,Prabhu SD,Bhatnagar A

Mon Jun 01 00:00:00 UTC 2015

Glutathione S-transferase P protects against cyclophosphamide-induced cardiotoxicity in mice.

Toxicology and applied pharmacology

Conklin DJ,Haberzettl P,Jagatheesan G,Baba S,Merchant ML,Prough RA,Williams JD,Prabhu SD,Bhatnagar A

Mon Jun 01 00:00:00 UTC 2015

MicroRNA-133b targets glutathione S-transferase π expression to increase ovarian cancer cell sensitivity to chemotherapy drugs.

Drug design, development and therapy

Chen S,Jiao JW,Sun KX,Zong ZH,Zhao Y

Wed Jul 06 00:00:00 UTC 2016

MicroRNA-133b targets glutathione S-transferase π expression to increase ovarian cancer cell sensitivity to chemotherapy drugs.

Drug design, development and therapy

Chen S,Jiao JW,Sun KX,Zong ZH,Zhao Y

Wed Jul 06 00:00:00 UTC 2016

Growth hormone alters the glutathione S-transferase and mitochondrial thioredoxin systems in long-living Ames dwarf mice.

The journals of gerontology. Series A, Biological sciences and medical sciences

Rojanathammanee L,Rakoczy S,Brown-Borg HM

Wed Oct 01 00:00:00 UTC 2014

Growth hormone alters the glutathione S-transferase and mitochondrial thioredoxin systems in long-living Ames dwarf mice.

The journals of gerontology. Series A, Biological sciences and medical sciences

Rojanathammanee L,Rakoczy S,Brown-Borg HM

Wed Oct 01 00:00:00 UTC 2014

Effects of insulin-like growth factor 1 on glutathione S-transferases and thioredoxin in growth hormone receptor knockout mice.

Age (Dordrecht, Netherlands)

Rojanathammanee L,Rakoczy S,Kopchick J,Brown-Borg HM

Tue Mar 31 00:00:00 UTC 2015

Effects of insulin-like growth factor 1 on glutathione S-transferases and thioredoxin in growth hormone receptor knockout mice.

Age (Dordrecht, Netherlands)

Rojanathammanee L,Rakoczy S,Kopchick J,Brown-Borg HM

Tue Mar 31 00:00:00 UTC 2015

Dietary wolfberry upregulates carotenoid metabolic genes and enhances mitochondrial biogenesis in the retina of db/db diabetic mice.

Molecular nutrition & food research

Yu H,Wark L,Ji H,Willard L,Jaing Y,Han J,He H,Ortiz E,Zhang Y,Medeiros DM,Lin D

Mon Jul 01 00:00:00 UTC 2013

Dietary wolfberry upregulates carotenoid metabolic genes and enhances mitochondrial biogenesis in the retina of db/db diabetic mice.

Molecular nutrition & food research

Yu H,Wark L,Ji H,Willard L,Jaing Y,Han J,He H,Ortiz E,Zhang Y,Medeiros DM,Lin D

Mon Jul 01 00:00:00 UTC 2013

Protection of cyanidin-3-glucoside against oxidative stress induced by acrylamide in human MDA-MB-231 cells.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Song J,Zhao M,Liu X,Zhu Y,Hu X,Chen F

Thu Aug 01 00:00:00 UTC 2013

Protection of cyanidin-3-glucoside against oxidative stress induced by acrylamide in human MDA-MB-231 cells.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Song J,Zhao M,Liu X,Zhu Y,Hu X,Chen F

Thu Aug 01 00:00:00 UTC 2013

Proteomic profiling of brain cortex tissues in a Tau transgenic mouse model of Alzheimer's disease.

Biochemical and biophysical research communications

Chang SH,Jung IS,Han GY,Kim NH,Kim HJ,Kim CW

Fri Jan 11 00:00:00 UTC 2013

Proteomic profiling of brain cortex tissues in a Tau transgenic mouse model of Alzheimer's disease.

Biochemical and biophysical research communications

Chang SH,Jung IS,Han GY,Kim NH,Kim HJ,Kim CW

Fri Jan 11 00:00:00 UTC 2013

Thioacetamide-induced Hepatocellular Necrosis Is Attenuated in Diet-induced Obese Mice.

Journal of toxicologic pathology

Shirai M,Arakawa S,Miida H,Matsuyama T,Kinoshita J,Makino T,Kai K,Teranishi M

Sat Jun 01 00:00:00 UTC 2013

Thioacetamide-induced Hepatocellular Necrosis Is Attenuated in Diet-induced Obese Mice.

Journal of toxicologic pathology

Shirai M,Arakawa S,Miida H,Matsuyama T,Kinoshita J,Makino T,Kai K,Teranishi M

Sat Jun 01 00:00:00 UTC 2013

Quantitative proteomic analysis of Niemann-Pick disease, type C1 cerebellum identifies protein biomarkers and provides pathological insight.

PloS one

Cologna SM,Jiang XS,Backlund PS,Cluzeau CV,Dail MK,Yanjanin NM,Siebel S,Toth CL,Jun HS,Wassif CA,Yergey AL,Porter FD

Tue Aug 26 00:00:00 UTC 2014

Quantitative proteomic analysis of Niemann-Pick disease, type C1 cerebellum identifies protein biomarkers and provides pathological insight.

PloS one

Cologna SM,Jiang XS,Backlund PS,Cluzeau CV,Dail MK,Yanjanin NM,Siebel S,Toth CL,Jun HS,Wassif CA,Yergey AL,Porter FD

Tue Aug 26 00:00:00 UTC 2014

Bioinformatics

Protein Aliases: Chain 7; deafness, X-linked 7; epididymis secretory protein Li 22; fatty acid ethyl ester synthase III; Glutathione S-transferase P; Glutathione S-transferase P 1; glutathione S-transferase pi 2; glutathione S-transferase, pi 2; Glutathione-S-transferase placental enzyme pi type; glutathione-S-transferase, pi 1; Glutathione-S-transferase, placental enzyme pi type; GST 7-7; GST class-pi; Gst p-1; Gst P1; GST YF-YF; GST-piB; GSTP1-1; HGNC:4638; Preadipocyte growth factor

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Gene Aliases: DFN7; FAEES3; GST-P; GST3; GSTP; GSTP1; Gstp2; GstpiB; HEL-S-22; PI

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UniProt ID: (Human) P09211, (Rat) P04906, (Mouse) P19157

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Entrez Gene ID: (Human) 2950, (Rat) 24426, (Mouse) 14870

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Function(s)

glutathione transferase activity glutathione peroxidase activity protein binding drug binding JUN kinase binding kinase regulator activity S-nitrosoglutathione binding dinitrosyl-iron complex binding glutathione binding nitric oxide binding transferase activity

Process(es)

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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GSTP1 Polyclonal Antibody

GSTP1 Antibody (15902-1-AP) in ICC/IF

Product Details

15902-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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