Invitrogen

GSTP1 Polyclonal Antibody

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Datasheet
Protocols
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Datasheet
Protocols
Questions & Answers

Product Details

PA5-77994

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:10,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:1,000
-

Immunocytochemistry (ICC/IF)

1:100-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human GSTP1. The exact sequence is proprietary.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7, with 20% glycerol

Contains

0.01% thimerosal

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2735887

Product Specific Information

Positive Control: A431, HeLa, HepG2

Predicted Reactivity: Rat (100%), Dog (100%), Rhesus Monkey (100%), Bovine (100%)

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. This GST family member is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: deafness, X-linked 7; epididymis secretory protein Li 22; fatty acid ethyl ester synthase III; Glutathione S-transferase P; Glutathione S-transferase P 1; GST class-pi; Gst p-1; Gst P1; GST YF-YF; GST-piB; GSTP1-1; HGNC:4638; Preadipocyte growth factor

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Gene Aliases: DFN7; FAEES3; GST3; GSTP; GSTP1; GstpiB; HEL-S-22; PI

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UniProt ID: (Human) P09211, (Mouse) P19157

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Entrez Gene ID: (Human) 2950, (Mouse) 14870

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Function(s)
glutathione transferase activity glutathione peroxidase activity protein binding drug binding JUN kinase binding kinase regulator activity S-nitrosoglutathione binding dinitrosyl-iron complex binding glutathione binding nitric oxide binding transferase activity
Process(es)
response to reactive oxygen species negative regulation of acute inflammatory response negative regulation of protein kinase activity glutathione metabolic process xenobiotic metabolic process central nervous system development negative regulation of biosynthetic process negative regulation of tumor necrosis factor-mediated signaling pathway oligodendrocyte development organ regeneration response to estradiol negative regulation of interleukin-1 beta production negative regulation of tumor necrosis factor production cellular response to insulin stimulus regulation of stress-activated MAPK cascade negative regulation of stress-activated MAPK cascade positive regulation of superoxide anion generation response to L-ascorbic acid common myeloid progenitor cell proliferation nitric oxide storage negative regulation of apoptotic process negative regulation of I-kappaB kinase/NF-kappaB signaling response to amino acid negative regulation of MAP kinase activity negative regulation of MAPK cascade negative regulation of JUN kinase activity linoleic acid metabolic process response to ethanol response to mercury ion negative regulation of fibroblast proliferation negative regulation of nitric-oxide synthase biosynthetic process regulation of ERK1 and ERK2 cascade negative regulation of ERK1 and ERK2 cascade negative regulation of leukocyte proliferation cellular response to lipopolysaccharide cellular response to epidermal growth factor stimulus cellular response to glucocorticoid stimulus cellular response to cell-matrix adhesion negative regulation of monocyte chemotactic protein-1 production cellular oxidant detoxification glutathione derivative biosynthetic process negative regulation of extrinsic apoptotic signaling pathway metabolic process negative regulation of neutrophil aggregation negative regulation of peroxidase activity
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