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Product Details
24405-1-AP
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
GTF2E1 Fusion Protein Ag19794 (88-439 aa encoded by BC156997)
Conjugate
Form
Liquid
Concentration
0.39 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: RHNYYFINY RTLVNVVKYK LDHMRRRIET DERDSTNRAS FKCPVCSSTF TDLEANQLFD PMTGTFRCTF CHTEVEEDES AMPKKDARTL LARFNEQIEP IYALLRETED VNLAYEILEP EPTEIPALKQ SKDHAATTAG AASLAGGHHR EAWATKGPSY EDLYTQNVVI NMDDQEDLHR ASLEGKSAKE RPIWLRESTV QGAYGSEDMK EGGIDMDAFQ EREEGHAGPD DNEEVMRALL IHEKKTSSAM AGSVGAAAPV TAANGSDSES ETSESDDDSP PRPAAVAVHK REEDEEEDDE FEEVADDPIV MVAGRPFSYS EVSQRPELVA QMTPEEKEAY IAMGQRMFED LFE (88-439 aa encoded by BC156997)
Target Information
The general transcription factor TFIIE has an essential role in eukaryotic transcription initiation together with RNA polymerase II and other general factors. Human TFIIE consists of two subunits of relative molecular mass 57, 000 (TFIIE-alpha) and 34, 000 (TFIIE-beta) and joins the preinitiation complex after RNA polymerase II and TFIIF. TFIIE-alpha is necessary for transcription initiation together with TFIIE-beta, and recombinant TFIIE-alpha can fully replace the natural subunit in an in vitro transcription assay. Its sequence contains several interesting structural motifs (leucine repeat, zinc finger and helix-turn-helix) and sequence similarities to bacterial sigma factors that suggest direct involvement in the regulation of transcription initiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: General transcription factor IIE 56 kDa subunit; General transcription factor IIE subunit 1; general transcription factor IIE, polypeptide 1, alpha 56kDa; TFIIE alpha subunit; TFIIE-alpha; Transcription initiation factor IIE subunit alpha
Gene Aliases: FE; GTF2E1; TF2E1; TFIIE-A
UniProt ID: (Human) P29083
Entrez Gene ID: (Human) 2960
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