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Product Details
11557-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
GTPBP2 Fusion Protein Ag2113 (183-532 aa encoded by BC028347)
Conjugate
Form
Liquid
Concentration
0.17 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: SKMITFIDL AGHHKYLHTT IFGLTSYCPD CALLLVSANT GIAGTTREHL GLALALKVPF FIVVSKIDLC AKTTVERTVR QLERVLKQPG CHKVPMLVTS EDDAVTAAQQ FAQSPNVTPI FTLSSVSGES LDLLKVFLNI LPPLTNSKEQ EELMQQLTEF QVDEIYTVPE VGTVVGGTLS SGICREGDQL VVGPTDDGCF LELRVCSIQR NRSACRVLRA GQAATLALGD FDRALLRKGM VMLSPEMNPT ICSVFEAEIV LLFHATTFRR GFQVTVHVGN VRQTAVVEKI HAKDKLRTGE KAVVRFRFLK HPEYLKVGAK LLFREGVTKG IGHVTDVQAI TAGEAQANMG F (183-532 aa encoded by BC028347)
Target Information
Small G proteins act as molecular switches for regulation of variety of cellular processes, such as nuclear transport, signal transduction, membrane trafficking and protein synthesis. GTPBP2 (GTP-binding protein 2) is a 602 amino acid G protein that is expressed in kidney, skeletal muscle, testis, brain and thymus, though it is not detected in liver. Expression of GTPBP2 is enhanced by ©-interferon stimulation in HeLa cells, THP-1 cells and thioglycollate-elicited mouse peritoneal macrophages. There are four isoforms of GTPBP2 that are expressed as a result of alternative splicing events. Since mutation of the gene encoding GTPBP1 does not lead to any phenotypic abnormalities, it is thought that there may be a genetic redundancy to make up for GTPBP1 lack-of-function. GTPBP2 shares 44% sequence similarity with GTPBP1 and also overlaps in expression pattern, suggesting that the GTPBP2 gene may compensate for GTPBP1 genetic abnormalities.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GTP-binding protein 2; GTP-binding-like protein 2; GTPBP2
Gene Aliases: GTPBP2; nmf205
UniProt ID: (Human) Q9BX10, (Mouse) Q3UJK4
Entrez Gene ID: (Human) 54676, (Mouse) 56055, (Rat) 363195
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