Proteintech

GTSE1 Polyclonal Antibody

View all (10) GTSE1 antibodies

Questions & Answers

Questions & Answers

Antibody Testing Data (6)

GTSE1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

GTSE1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 6

GTSE1 Antibody (21319-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human liver cancer tissue slide using 21319-1-AP ( GTSE1 antibody) at dilution of 1:200 (under 40x lens).

GTSE1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

GTSE1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

GTSE1 Antibody in Western Blot (WB)

GTSE1 Antibody in Western Blot (WB)

GTSE1 Antibody in Western Blot (WB)

GTSE1 Antibody in Western Blot (WB)

Product Image Gallery

GTSE1 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human liver cancer tissue slide using 21319-1-AP ( GTSE1 antibody) at dilution of 1:200 (under 40x lens).

GTSE1 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human liver cancer tissue slide using 21319-1-AP ( GTSE1 antibody) at dilution of 1:200 (under 10x lens).

GTSE1 Antibody in Western Blot (WB) — Various lysates were subjected to SDS PAGE followed by western blot with (Product # 21319-1-AP) GTSE1 antibody at dilution of 1:4,000 incubated at room temperature for 1.5 hours.

GTSE1 Antibody in Western Blot (WB) — K-562 cells were subjected to SDS PAGE followed by western blot with 21319-1-AP (GTSE1 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

GTSE1 Antibody in Western Blot (WB) — HeLa cells were subjected to SDS PAGE followed by western blot with 21319-1-AP (GTSE1 Antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

GTSE1 Antibody in Western Blot (WB) — L02 cells were subjected to SDS PAGE followed by western blot with 21319-1-AP ( GTSE1 Antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

Product Details

21319-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 7 publications 7 publications

Immunohistochemistry (IHC)

-

View 6 publications 6 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

-

Immunocytochemistry (ICC/IF)

-

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

GTSE1 Fusion Protein Ag13497 (416-720 aa encoded by BC006325)

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.3 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: CAWSESSQL NKTRSIRRRD SCLNSKTKVM PTPTNQFKIP KFSIGDSPDS STPKLSRAQR PQSCTSVGRV TVHSTPVRRS SGPAPQSLLS ARRVSALPTP ASRRCSGLPP MTPKTMPRAV GSPLCVPARR RSSEPRKNSA MRTEPTRESN RKTDSRLVDV SPDRGSPPSR VPQALNFSPE ESDSTFSKST ATEVAREEAK PGGDAAPSEA LLVDIKLEPL AVTPDAASQP LIDLPLIDFC DTPEAHVAVG SESRPLIDLM TNTPDMNKNV AKPSPVVGQL IDLSSPLIQL SPEADKENVD SPLLKF (416-720 aa encoded by BC006325)

Target Information

The protein encoded by this gene is only expressed in the S and G2 phases of the cell cycle, where it colocalizes with cytoplasmic tubulin and microtubules. In response to DNA damage, the encoded protein accumulates in the nucleus and binds the tumor suppressor protein p53, shuttling it out of the nucleus and repressing its ability to induce apoptosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

G2 and S phase-expressed-1 induces chromosomal instability in esophageal squamous cell carcinoma cells and inhibits cell apoptosis through ROS/JNK signaling.

Molecular carcinogenesis

Zhang M,Wang X,Liu C,Zheng Z,Wan J,Yang Y,Chen S,Liu H

Wed Feb 01 00:00:00 UTC 2023

G2 and S phase-expressed-1 induces chromosomal instability in esophageal squamous cell carcinoma cells and inhibits cell apoptosis through ROS/JNK signaling.

Molecular carcinogenesis

Zhang M,Wang X,Liu C,Zheng Z,Wan J,Yang Y,Chen S,Liu H

Wed Feb 01 00:00:00 UTC 2023

G2 and S phase-expressed-1 induces chromosomal instability in esophageal squamous cell carcinoma cells and inhibits cell apoptosis through ROS/JNK signaling.

Molecular carcinogenesis

Zhang M,Wang X,Liu C,Zheng Z,Wan J,Yang Y,Chen S,Liu H

Wed Feb 01 00:00:00 UTC 2023

GTSE1 promotes tumor growth and metastasis by attenuating of KLF4 expression in clear cell renal cell carcinoma.

Laboratory investigation; a journal of technical methods and pathology

Chen W,Wang H,Lu Y,Huang Y,Xuan Y,Li X,Guo T,Wang C,Lai D,Wu S,Zhao W,Mai H,Li H,Wang B,Ma X,Zhang X

Thu Sep 01 00:00:00 UTC 2022

GTSE1 promotes tumor growth and metastasis by attenuating of KLF4 expression in clear cell renal cell carcinoma.

Laboratory investigation; a journal of technical methods and pathology

Chen W,Wang H,Lu Y,Huang Y,Xuan Y,Li X,Guo T,Wang C,Lai D,Wu S,Zhao W,Mai H,Li H,Wang B,Ma X,Zhang X

Thu Sep 01 00:00:00 UTC 2022

GTSE1 promotes prostate cancer cell proliferation via the SP1/FOXM1 signaling pathway.

Laboratory investigation; a journal of technical methods and pathology

Lai W,Zhu W,Li X,Han Y,Wang Y,Leng Q,Li M,Wen X

Sat May 01 00:00:00 UTC 2021

GTSE1 promotes prostate cancer cell proliferation via the SP1/FOXM1 signaling pathway.

Laboratory investigation; a journal of technical methods and pathology

Lai W,Zhu W,Li X,Han Y,Wang Y,Leng Q,Li M,Wen X

Sat May 01 00:00:00 UTC 2021

GTSE1 promotes prostate cancer cell proliferation via the SP1/FOXM1 signaling pathway.

Laboratory investigation; a journal of technical methods and pathology

Lai W,Zhu W,Li X,Han Y,Wang Y,Leng Q,Li M,Wen X

Sat May 01 00:00:00 UTC 2021

GTSE1 promotes prostate cancer cell proliferation via the SP1/FOXM1 signaling pathway.

Laboratory investigation; a journal of technical methods and pathology

Lai W,Zhu W,Li X,Han Y,Wang Y,Leng Q,Li M,Wen X

Sat May 01 00:00:00 UTC 2021

G2 and S phase-expressed-1 acts as a putative tumor promoter in cervical cancer by enhancing Wnt/β-catenin signaling via modulation of GSK-3β.

Environmental toxicology

Guo W,Zhu J,Zhu Y,Wang K

Sun Aug 01 00:00:00 UTC 2021

lncRNA LINC00665 Stabilized by TAF15 Impeded the Malignant Biological Behaviors of Glioma Cells via STAU1-Mediated mRNA Degradation.

Molecular therapy. Nucleic acids

Ruan X,Zheng J,Liu X,Liu Y,Liu L,Ma J,He Q,Yang C,Wang D,Cai H,Li Z,Liu J,Xue Y

Fri Jun 05 00:00:00 UTC 2020

GTSE1 is involved in breast cancer progression in p53 mutation-dependent manner.

Journal of experimental & clinical cancer research : CR

Lin F,Xie YJ,Zhang XK,Huang TJ,Xu HF,Mei Y,Liang H,Hu H,Lin ST,Luo FF,Lang YH,Peng LX,Qian CN,Huang BJ

Mon Apr 08 00:00:00 UTC 2019

High G2 and S-phase expressed 1 expression promotes acral melanoma progression and correlates with poor clinical prognosis.

Cancer science

Xu T,Ma M,Chi Z,Si L,Sheng X,Cui C,Dai J,Yu S,Yan J,Yu H,Wu X,Tang H,Yu J,Kong Y,Guo J

Fri Jun 01 00:00:00 UTC 2018

High G2 and S-phase expressed 1 expression promotes acral melanoma progression and correlates with poor clinical prognosis.

Cancer science

Xu T,Ma M,Chi Z,Si L,Sheng X,Cui C,Dai J,Yu S,Yan J,Yu H,Wu X,Tang H,Yu J,Kong Y,Guo J

Fri Jun 01 00:00:00 UTC 2018

Expression profiling of small intestinal neuroendocrine tumors identifies subgroups with clinical relevance, prognostic markers and therapeutic targets.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc

Andersson E,Arvidsson Y,Swärd C,Hofving T,Wängberg B,Kristiansson E,Nilsson O

Wed Jun 01 00:00:00 UTC 2016

Expression profiling of small intestinal neuroendocrine tumors identifies subgroups with clinical relevance, prognostic markers and therapeutic targets.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc

Andersson E,Arvidsson Y,Swärd C,Hofving T,Wängberg B,Kristiansson E,Nilsson O

Wed Jun 01 00:00:00 UTC 2016

Silencing GTSE-1 expression inhibits proliferation and invasion of hepatocellular carcinoma cells.

Cell biology and toxicology

Guo L,Zhang S,Zhang B,Chen W,Li X,Zhang W,Zhou C,Zhang J,Ren N,Ye Q

Mon Aug 01 00:00:00 UTC 2016

Silencing GTSE-1 expression inhibits proliferation and invasion of hepatocellular carcinoma cells.

Cell biology and toxicology

Guo L,Zhang S,Zhang B,Chen W,Li X,Zhang W,Zhou C,Zhang J,Ren N,Ye Q

Mon Aug 01 00:00:00 UTC 2016

Silencing GTSE-1 expression inhibits proliferation and invasion of hepatocellular carcinoma cells.

Cell biology and toxicology

Guo L,Zhang S,Zhang B,Chen W,Li X,Zhang W,Zhou C,Zhang J,Ren N,Ye Q

Mon Aug 01 00:00:00 UTC 2016

Silencing GTSE-1 expression inhibits proliferation and invasion of hepatocellular carcinoma cells.

Cell biology and toxicology

Guo L,Zhang S,Zhang B,Chen W,Li X,Zhang W,Zhou C,Zhang J,Ren N,Ye Q

Mon Aug 01 00:00:00 UTC 2016

Bioinformatics

Protein Aliases: G two S phase expressed protein 1; G-2 and S-phase expressed 1; G2 and S phase-expressed protein 1; GTSE-1; Protein B99; Protein B99 homolog

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Gene Aliases: B99; Gtse-1; GTSE1; RGD1563164

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UniProt ID: (Human) Q9NYZ3, (Mouse) Q8R080

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Entrez Gene ID: (Human) 51512, (Rat) 300126, (Mouse) 29870

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molecular_function protein binding

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest microtubule-based process positive regulation of cell migration proteasome-mediated ubiquitin-dependent protein catabolic process positive regulation of protein export from nucleus protein stabilization positive regulation of protein localization to nucleus regulation of cell cycle G2/M phase transition negative regulation of microtubule binding

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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